B.Pharmacy (Semester VIII) Examination, 2018
(New CGPA Pattern) Pharmacology Iv
Day and Date Wednesday, 16-5-2018 Max. Marks 70
Time 3.00 p.m. to 6.00 p.m.
I. Multiple Choice Questions. (15×1=15)
Which antibiotic is primarily bacteriostatic but becomes bactericidal at higher concentrations
Erythromycin Tetracycline
Chloramphenicol Ampicillin
Cross-resistance is more commonly seen between
Bacteriostatic and bactericidal drugs
Chemically or mechanistically related drugs
Antibacterial and antiviral drugs
Narrow-spectrum and broad-spectrum
The most important reason for highly restricted use of penicillin G injections in present day therapeutics is its
Narrow spectrum of activity
Potential to cause hypersensitivity reaction
Short duration of action
Neurotoxicity
Chloramphenicol belongs to the class of
Macrolide antibiotics Nitroimidazoles
Nitrobenzene derivative Aminoglycosides
Mesna is administered with cyclophosphamide and ifosphamide to
Potentiate their cytotoxic action
Retard their renal excretion
Block their emetic action
Ameliorate cystitis caused by them
Which one of the following is having least nephrotoxic property
Neomycin Streptomycin
Kanamycin Framycetin
Select the group of antibiotics having an antimalarial effect
Aminoglycosides Tetracyclins
Carbapenems Penicillins
The sensitive Mycobacteria convert Isoniazid in to an active metabolite by enzyme
Aminoglycosidase Penicillinase
Catalase-peroxidase Mycolic acid syntheses
Select the drug of choice for the treatment of extraluminal amebiasis
Iodoquinol Metronidazole
Diloxanide Tetracycline
10) Streptomycin binds to and inhibits protein synthesis.
50S ribosomal subunit
Interphase of 30S-50S ribosomal subunits
30S ribosomal subunit
80S ribosome
11) Select the cell cycle nonspecific antineoplastic drug.
Vincristine Bleomycin
Methotrexate 5-Fluorouracil
12) Dizziness, nausea, omiting, diarrhoea, abdominal pain and sinus bradycardia are dose-related reactions of
Terbinafine Primaquine
Mefloquine Pyrimethamine
13) All of the following antiviral drugs are the analogs of nucleosides, EXCEPT
Acyclovir Zidovudine
Saquinavir Didanozine
14) Dapsone has the same mechanism of action as that of
Mefloquine Tetracycline
Erythromycin Sulfonamides
15) Clavulanic acid is combined with amoxicillin because
It kills bacteria that are not killed by amoxicillin
It retards renal excretion of amoxicillin
It counteracts the adverse effects of amoxicillin
It inhibits beta lactamases that destroy amoxicillin
II. Answer any five.
Classify antileprotic drugs and write the mechanism of action of dapsone.
Write the mechanism of action of vinca alkaloids and taxanes.
Name the topical and systemic aminoglycoside antibiotics and write their shared toxicities.
What are macrolide antibiotics And write its mechanism of action.
Write the advantages and disadvantages of the combined use of antimicrobial agents.
What is tuberculosis Write the mechanism of action of isoniazid.
III. Answer any three. (3×10=30)
Classify anticancer drugs with examples and write mechanism of action and uses of alkylating agents.
What are beta-lactam antibiotics Classify penicillin with suitable examples and explain how penicillin-G act as a bactericidal agent.
What are general toxicities of cytotoxic drugs Write the mechanism of development of microbial resistance towards antimicrobial agents.
Write the mechanism of action and uses of tetracyclines and sulfonamides.