B.Pharmacy (Semester VI) Examination, 2017
CLINICAL PHARMACOLOGY
(New CGPA)
Day and Date Friday, 19-5-2017 Total Marks 70
Time 10.30 a.m. to 1.30 p.m.
1. MCQ/Objective Type Questions (15 ×1=15)
The main objective of clinical pharmacology is drug therapy.
Optimize Minimise
Non optimise Maximise
Clinical pharmacokinetic can be applied in daily practice for drugs with
therapeutics index.
Low Moderate High Very high
Experimental therapeutic study in normal healthy volunteers help to determine
the
Safety Tolerability
Pharmacokinetics All of the above
If sufficiently high doses of the drugs are administered is called as
of drfugs.
Side effects Adverse drug reactions
Toxic effects Intolerance
It is advisable to mixing drugs in infusion solutions.
Avoid Make
Practice None of the above
The primary goal of the case study is to develop the
Self learning Critical thinking
Decision making All of the above
Differences in the rate of drug absorption in the neonate may be due to

Relative achlorhydria
Longer gastric emptying time
High levels of intestinal beta-glucuronidase activity
All of the above
The credit for initiating and establishing clinical pharmacology in India goes to

Harry Gold Prof. U.K. Sheth
Clinician None of the above
By knowing the half-life of a drug, one may estimate to reach a
steady state.
Time to maximal response Loading dose
Dosage alteration Choosing a formulation
10) trials are aimed to ensure that the treatment is safe to
humans.
Preclinical Clinical
Animal studies None of the above
11) is the last phase of clinical trial.
Post licensing Therapeutic confirmation
Therapeutic exploration Human pharmacology
12) macromolecule can act as complete antigens.
Proteins Peptides
Dextrans All of the above
13) may also be implicated in drug interactions.
Non prescribing drugs Food
Both a and b None of the above
14) is major reason for the increased vulnerability of old people
to drugs.
Reduced homeostatic control Loss of reserve capacity
Impaired manual dexterity All of the above
15) Recommended pediatric doses generally stated as
Milligrams/Kg Micrograms/Kg
Nanograms/Kg None of the above
2. Answer any five of the following
Enlist the role of Clinical Pharmacologist.
What is 'Individualization of Drug Therapy' Comment on the factors affecting it.
Write a note on Informed consent.
Explain shortly the allergy in response to drug.
Give the uses of drug interaction information.
How the pediatric doses can be calculated Give the importance of drug
therapy in neonates.
3. Answer any three of the following (3×10=30)
Discuss in detail chronic pharmacology, add a note on dosing of drugs in
hepatic disease.
Describe in detail pharmacovigilance and safety data reporting.
What is COPD Present case study including different signs and symptoms,
importance of non-pharmacological therapy, importance of smoking cessation
and educate patients etc.
Define Adverse Drug Reaction. Describe any three adverse drug reaction
with suitable example.