Exam Details
| Subject | medicinal chemistry – ii | |
| Paper | ||
| Exam / Course | b. pharmacy | |
| Department | ||
| Organization | solapur university | |
| Position | ||
| Exam Date | 12, May, 2017 | |
| City, State | andhra pradesh, solapur |
Question Paper
B.Pharm. (Semester VI) (New-CGPA) Examination, 2017
MEDICINAL CHEMISTRY II
Day and Date Friday, 12-5-2017 Total Marks 70
Time 10.30 a.m. to 1.30 p.m.
1. Multiple Choice Questions. (15×1=15)
The intermediate acting sulphonamide is
Sulphamethoxazole Sulphisaxazole
Sulphamethizole Sulphadimethoxine
5-flurouracil showing major antineoplastic activity due to presence of
group.
2-fluro 3-fluro
5-fluro Uracil
is used as Quinoline antibacterial agent.
Amantidine Chloroquine
Lamivudine Ciprofloxacin
Isoniazide is generally synthesized by using
4-methyl pyridine 3-methyl pyridine
2-methyl pyridine None of above
Procarbazine shows antineoplastic action by which process
Acetylating DNA Alkylation of DNA
Amination of DNA Brominating DNA
drug inhibits DNA gyrase enzyme.
Norfloxacine Ethionamide
Sulphamoxol Quinacrine
Which of the following ring is present in Sulphaguanidine
Guanidine Furan
Pyrimide Thiazole
used in U.T.I.
Aspirin Mebendazole
Paracetamol Trimethoprim
drug is metabolised by process "Sulphur stripping".
Busalphan Sulphapyridine
Chlorambucil Nitrogen mustard
10) Chloroquine inhibits which type of enzyme.
DNA-polymerase DNA-hydrase
DNA-lygase DNA-isomerase
11) drug is giving good results in HIV patient.
Acyclovir Amantidine
Zidovudine Vidarabin
12) A free radical alkylating drug is
Carmustine Thiotepa
Procarbazine Altretamine
13) is 9-amioacridine derivative used as antimalarial.
Quinacrine Chloroquine
Primaquine Mefloquine
14) The heterocyclic ring present in vinca alkaloids
Pyrrol Pyrazole
Quinazoline Indole
15) is mitotic spindle poison used as antifungal agent.
Clotrimazole Econazole
Butacanazole Griseofulvin
2. Answer any five of the following questions.
Discuss on combination therapy used in treatment of tuberculosis.
Explain in details of life cycle of cancer.
Describe SAR and MOA of sulphonamides.
Justify "Azole derivatives as potent antifungal agents with suitable example".
Describe in detail life cycle of malarial parasite.
Write a note on reverse transcriptase inhibitors, classify with e.g.
3. Answer the following questions. (3×10=30)
Write MOA and SAR of quinoline antibacterial agent draw the structure of
norfloxacine and nalidixic acid.
Outline synthesis and uses of methotrexate, chloroquine, ethambutol,
acyclovir.
Discuss various steps involved in viral replication and name the drugs acting
at different steps.
MEDICINAL CHEMISTRY II
Day and Date Friday, 12-5-2017 Total Marks 70
Time 10.30 a.m. to 1.30 p.m.
1. Multiple Choice Questions. (15×1=15)
The intermediate acting sulphonamide is
Sulphamethoxazole Sulphisaxazole
Sulphamethizole Sulphadimethoxine
5-flurouracil showing major antineoplastic activity due to presence of
group.
2-fluro 3-fluro
5-fluro Uracil
is used as Quinoline antibacterial agent.
Amantidine Chloroquine
Lamivudine Ciprofloxacin
Isoniazide is generally synthesized by using
4-methyl pyridine 3-methyl pyridine
2-methyl pyridine None of above
Procarbazine shows antineoplastic action by which process
Acetylating DNA Alkylation of DNA
Amination of DNA Brominating DNA
drug inhibits DNA gyrase enzyme.
Norfloxacine Ethionamide
Sulphamoxol Quinacrine
Which of the following ring is present in Sulphaguanidine
Guanidine Furan
Pyrimide Thiazole
used in U.T.I.
Aspirin Mebendazole
Paracetamol Trimethoprim
drug is metabolised by process "Sulphur stripping".
Busalphan Sulphapyridine
Chlorambucil Nitrogen mustard
10) Chloroquine inhibits which type of enzyme.
DNA-polymerase DNA-hydrase
DNA-lygase DNA-isomerase
11) drug is giving good results in HIV patient.
Acyclovir Amantidine
Zidovudine Vidarabin
12) A free radical alkylating drug is
Carmustine Thiotepa
Procarbazine Altretamine
13) is 9-amioacridine derivative used as antimalarial.
Quinacrine Chloroquine
Primaquine Mefloquine
14) The heterocyclic ring present in vinca alkaloids
Pyrrol Pyrazole
Quinazoline Indole
15) is mitotic spindle poison used as antifungal agent.
Clotrimazole Econazole
Butacanazole Griseofulvin
2. Answer any five of the following questions.
Discuss on combination therapy used in treatment of tuberculosis.
Explain in details of life cycle of cancer.
Describe SAR and MOA of sulphonamides.
Justify "Azole derivatives as potent antifungal agents with suitable example".
Describe in detail life cycle of malarial parasite.
Write a note on reverse transcriptase inhibitors, classify with e.g.
3. Answer the following questions. (3×10=30)
Write MOA and SAR of quinoline antibacterial agent draw the structure of
norfloxacine and nalidixic acid.
Outline synthesis and uses of methotrexate, chloroquine, ethambutol,
acyclovir.
Discuss various steps involved in viral replication and name the drugs acting
at different steps.
Other Question Papers
Subjects
- anatomy, physiology and health education – i
- anatomy, physiology and health education – ii
- biochemistry
- biochemistry – i
- biochemistry – ii
- biopharmaceutics
- biotechnology
- clinical pharmacology
- herbal technology
- human anatomy and physiology – i
- human anatomy and physiology – ii
- medicinal chemistry – i
- medicinal chemistry – ii
- medicinal chemistry – iv
- microbiology
- modern dispensing and hospital pharmacy
- novel drug delivery systems
- organic chemistry – i
- organic chemistry – ii
- organic chemistry – iii
- pathophysiology (new cbcs)
- pathophysiology and clinical biochemistry – i
- pathophysiology and clinical biochemistry – ii
- pharmaceutical analysis – i
- pharmaceutical analysis – ii
- pharmaceutical analysis – iv
- pharmaceutical analysis – v
- pharmaceutical analysis – vi
- pharmaceutical busines management
- pharmaceutical engineering
- pharmaceutical enginering
- pharmaceutical inorganic chemistry
- pharmaceutical jurisprudence
- pharmaceutical microbiology
- pharmaceutical organic chemistry – ii
- pharmaceutical organic chemistry –i
- pharmaceutics – i (new cbcs)
- pharmaceutics – i (old-cbcs pattern)
- pharmaceutics – ii
- pharmaceutics – iii
- pharmaceutics – iv
- pharmacognosy – i
- pharmacognosy – ii
- pharmacognosy – iii
- pharmacology – i (new) (cbcs pattern)
- pharmacology – ii
- pharmacology – ii (cgpa pattern)
- pharmacology – iv
- physical pharmaceutics – i
- physical pharmacy – i
- physical pharmacy – ii
- sterile dosage forms