Exam Details
| Subject | medicinal chemistry – ii | |
| Paper | ||
| Exam / Course | b. pharmacy | |
| Department | ||
| Organization | solapur university | |
| Position | ||
| Exam Date | October, 2018 | |
| City, State | andhra pradesh, solapur |
Question Paper
B.Pharm. (Semester VI) (CGPA) Examination, 2018
Medicinal chemistry II
Day and Date Wednesday, 12-12-2018 Max. Marks 70
Time 2.30 p.m. to 5.30 p.m.
1. Multiple Choice Questions (15×1=15)
Dapsone Rifampin Clofazimine combination therapy is used in treating
Fungal Cancer
Tuberculosis Aids
The short acting Sulphonamide is
S ulphamethizole S ulphamethoxypyridazine
S ulphamethoxazole S ulphalene
I dentify the important enzyme in viral replication process
Hydrase I somerase
Reverse transcriptase Ligase
Dacarbazine shows anti-neoplastic action by which process
Alkylation of DNA Acetylating DNA
Amination of DNA Brominating DNA
Chloroquine is synthesized from
m-chloroaniline o-chloroaniline
p-chloroaniline 2-bromoaniline
Which of the antineoplastic agent is metabolized by xanthine oxidase
6-mercaptopurine Vincristine
Chlorambucil 6-thioguanine
Which of the drug is DHFR inhibitor
Chloroquine PAS
Trimethoprim S ulfadiazine
P.T.O.
Set P
SLR-TV 39 *SLRTV39*
Nalidixic acid inhibit enzyme.
Topoisomerase IV Topoisomerase I
Ligase None of above
Clotrimazole is a combination of
S ulphadiazine and Trimethoprim
S ulphamethoxazole and Trimethoprim
S ulphamethoxazole and Sulphadia
S ulphamethoxazole and Pyrimethamine
10) I dentify folic acid antagonists agent from following
Methotrexate Busulphan
Cisplatin Taxol
11) is used as Quinoline antibacterial agent.
Sparfloxacine Trimethoprim
Nevirapine Griseofulvin
12) Quinacrine is derivatives of
9-aminoacridine 4-aminoquinoline
8-aminoquinoline 6-aminoquinoline
13) N-1 position of Norfloxacine is occupied by which group
Cyclopropyl Ethyl
Methyl Piperazine
14) A potent inhibitor of thymidylate synthatase is
Naftifine 5-flucytosine
Ciclopirax Ketocanazole
15) Antifungal antibiotic is
Nystatin Nafimidine
Tolnaftate Clotrimazole
2. Answer any five of the following questions
Give complete account of DOT therapy.
Discuss in problem faced in cancer chemotherapy.
Set P
*SLRTV39* SLR-TV 39
Write a note on 4-aminoquinoline and write the synthesis of chloroquine.
Explain MOA SAR of Ethambutal with adverse reaction.
Write a note on azole derivatives.
Explain SAR and MOA of ciprofloxacin as antibacterial agent.
3. Answer any three of the following questions (3×10=30)
Outline the synthesis of Methotrxate, Acyclovir, Chloroquine.
Define and classify antineoplastic agent with suitable eg. explain MOA of
Alkylating agent with eg.
Classify antimalerial drugs. Explain life cycle of parasite and drug acting
on the various stages.
Classify anti-TB drug and explain MOA, SAR adverse effect and
synthesis of Para amino salicylic acid.
Medicinal chemistry II
Day and Date Wednesday, 12-12-2018 Max. Marks 70
Time 2.30 p.m. to 5.30 p.m.
1. Multiple Choice Questions (15×1=15)
Dapsone Rifampin Clofazimine combination therapy is used in treating
Fungal Cancer
Tuberculosis Aids
The short acting Sulphonamide is
S ulphamethizole S ulphamethoxypyridazine
S ulphamethoxazole S ulphalene
I dentify the important enzyme in viral replication process
Hydrase I somerase
Reverse transcriptase Ligase
Dacarbazine shows anti-neoplastic action by which process
Alkylation of DNA Acetylating DNA
Amination of DNA Brominating DNA
Chloroquine is synthesized from
m-chloroaniline o-chloroaniline
p-chloroaniline 2-bromoaniline
Which of the antineoplastic agent is metabolized by xanthine oxidase
6-mercaptopurine Vincristine
Chlorambucil 6-thioguanine
Which of the drug is DHFR inhibitor
Chloroquine PAS
Trimethoprim S ulfadiazine
P.T.O.
Set P
SLR-TV 39 *SLRTV39*
Nalidixic acid inhibit enzyme.
Topoisomerase IV Topoisomerase I
Ligase None of above
Clotrimazole is a combination of
S ulphadiazine and Trimethoprim
S ulphamethoxazole and Trimethoprim
S ulphamethoxazole and Sulphadia
S ulphamethoxazole and Pyrimethamine
10) I dentify folic acid antagonists agent from following
Methotrexate Busulphan
Cisplatin Taxol
11) is used as Quinoline antibacterial agent.
Sparfloxacine Trimethoprim
Nevirapine Griseofulvin
12) Quinacrine is derivatives of
9-aminoacridine 4-aminoquinoline
8-aminoquinoline 6-aminoquinoline
13) N-1 position of Norfloxacine is occupied by which group
Cyclopropyl Ethyl
Methyl Piperazine
14) A potent inhibitor of thymidylate synthatase is
Naftifine 5-flucytosine
Ciclopirax Ketocanazole
15) Antifungal antibiotic is
Nystatin Nafimidine
Tolnaftate Clotrimazole
2. Answer any five of the following questions
Give complete account of DOT therapy.
Discuss in problem faced in cancer chemotherapy.
Set P
*SLRTV39* SLR-TV 39
Write a note on 4-aminoquinoline and write the synthesis of chloroquine.
Explain MOA SAR of Ethambutal with adverse reaction.
Write a note on azole derivatives.
Explain SAR and MOA of ciprofloxacin as antibacterial agent.
3. Answer any three of the following questions (3×10=30)
Outline the synthesis of Methotrxate, Acyclovir, Chloroquine.
Define and classify antineoplastic agent with suitable eg. explain MOA of
Alkylating agent with eg.
Classify antimalerial drugs. Explain life cycle of parasite and drug acting
on the various stages.
Classify anti-TB drug and explain MOA, SAR adverse effect and
synthesis of Para amino salicylic acid.
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Subjects
- anatomy, physiology and health education – i
- anatomy, physiology and health education – ii
- biochemistry
- biochemistry – i
- biochemistry – ii
- biopharmaceutics
- biotechnology
- clinical pharmacology
- herbal technology
- human anatomy and physiology – i
- human anatomy and physiology – ii
- medicinal chemistry – i
- medicinal chemistry – ii
- medicinal chemistry – iv
- microbiology
- modern dispensing and hospital pharmacy
- novel drug delivery systems
- organic chemistry – i
- organic chemistry – ii
- organic chemistry – iii
- pathophysiology (new cbcs)
- pathophysiology and clinical biochemistry – i
- pathophysiology and clinical biochemistry – ii
- pharmaceutical analysis – i
- pharmaceutical analysis – ii
- pharmaceutical analysis – iv
- pharmaceutical analysis – v
- pharmaceutical analysis – vi
- pharmaceutical busines management
- pharmaceutical engineering
- pharmaceutical enginering
- pharmaceutical inorganic chemistry
- pharmaceutical jurisprudence
- pharmaceutical microbiology
- pharmaceutical organic chemistry – ii
- pharmaceutical organic chemistry –i
- pharmaceutics – i (new cbcs)
- pharmaceutics – i (old-cbcs pattern)
- pharmaceutics – ii
- pharmaceutics – iii
- pharmaceutics – iv
- pharmacognosy – i
- pharmacognosy – ii
- pharmacognosy – iii
- pharmacology – i (new) (cbcs pattern)
- pharmacology – ii
- pharmacology – ii (cgpa pattern)
- pharmacology – iv
- physical pharmaceutics – i
- physical pharmacy – i
- physical pharmacy – ii
- sterile dosage forms