B.Pharmacy (Semester III) Examination, 2017
(CGPA)
PATHOPHYSIOLOGY AND CLINICAL BIOCHEMISTRY I
Day and Date Tuesday, 16-5-2017 Total Marks 70
Time 3.00 p.m. to 6.00 p.m.
Instructions Figures to right indicate full marks.
Mention question and sub-question number compulsorily.
Appropriate charts/illustrations/algorithms may be drawn
whenever necessary.
I. Choose most appropriate alternative for following Multiple Choice Questions.
(15×1=15)
Match type of free radical in column A with number of excess electrons in
column B.
A B
Hydrogen Peroxide 3 excess electrons
ii) Superoxide free radical 2 excess electrons
iii) Hydroxyl free radical 1 excess electrons
i ii iii y i ii iii x
i ii iii x i ii iii z
Study of blood and diseases of blood is called as
Histology Hematology
Histopathology Cytopathology
Nuclear chromatin condenses and appears dark in case of
Pyknosis Karyorrhexis
Karyolysis All of these
Normal Serum Sodium ranges from mEq/Lit.
136-148 136-158
136-168 136-178
Increased HCO3
levels above 26 mEq/Lit is
Respiratory Acidosis Metabolic Acidosis
Respiratory Alkalosis Metabolic Alkalosis
Most common bacterium causing Pyelonephritis is
E.Coli Proteus
Pseudomonas None of these
Azotemia is elevated in blood.
Uric Acid BUN and Creatinine
Bilirubin Glucose
enlisted in cardinal signs of inflammation means
Pain Redness
Loss of Function Swelling
Bony growth at margins of articulating bones visible by X-ray in Osteoarthritis
is called
Osteoma Osteocyte
Osteoblast Osteophyte
10) Swelling of first toe of foot seen in early Gouty Arthritis is called
Pellagra Podagra
Viagra Contusion
11) Most common example of Tumor Suppressor Gene involved in more than
50% of cancers is
p53 BCL-XL
HER mTOR
12) is formation of new blood vessels within a tumor for its
nutrition and sustenance.
Metastasis Invasion
Hemorrhage Angiogenesis
13) and are characteristic appearances of
esophagus in Diffuse Esophageal Spasm and Esophageal Achalasia as
observed in Barium Swallow X-Ray films.
Cockscrew, Bird Beak Butterfly, Flea Bitten
Tombstone, Cheesy Gas bubble, Glassy
14) Which of the following Hepatitis viruses is a DNA virus
HAV HBV
HCV HDV
15) is a specific marker enzyme which is elevated in case of
Acute Pancreatitis.
Serum Amylase Enterokinase
Serum Lipase Lactate Dehydrogenase
II. Answer any five of the following.
Write role of free radicals in cell injury.
Illustrate with a diagram and explain different body fluid compartments.
Define Gall Stones. Explain types of gall stones briefly.
Define and classify Glomerulonephritis.
Define Cancer. Differentiate between Benign and Malignant Tumors.
Define Hypernatremia, Hyponatremia, Hyperkalemia and Hypokalemia with
their causes.
III. Answer any three of the following (3×10=30)
Derive pH of blood using Handerson Hasselbatch Equation. Briefly write about
different buffer systems in human body.
Describe etiopathogenesis and manifestations of Gastric and Duodenal Ulcers.
Write etiopathogenesis and manifestations of Acute Renal Failure.
Write definition, causes, pathogenesis, signs and symptoms of Osteoarthritis