M.Sc. DEGREE EXAMINATION, NOVEMBER 2017.
Third Semester
Bioinformatics
GENOMICS AND PHARMACOGENOMICS
(CBCS 2016 onwards)
Time 3 Hours Maximum 75 Marks
Part A (10 x 2 20)
Answer all questions.
All questions carry equal marks.
1. Define Pharmacophore.
2. What is Steric hindrance?
3. What is gene therapy?
4. Define recombinant sub unit Vaccine.
5. Define Polymorphism.
6. What is a Clinical Trial?
7. BLAST2.
8. What is splice site variation?
9. What is Geo?
10. Define epigenomics.
Sub. Code
502303
RW-851
2
Sp4
Part B x 5 25)
Answer all questions choosing either or
11. Explain in detail gene expression profiling.
Or
Salient features of genome annotation methods.
12. Explain the process of drug target discovery.
Or
Explain in detail Neural Networks.
13. Explain the basic concepts of genetic diseases.
Or
Compare different drug designing software
packages.
14. Explain the term ADME properties.
Or
Elaborate in detail adverse drug reactions.
15. Elaborate in detail integrated genomic maps.
Or
Explain briefly Combinatorial libraries.
RW-851
3
Sp4
Part C x 10 30)
Answer any three questions.
16. Explain in detail De Novo drug design and its application.
17. What are the applications of Comparative Genomics?
18. Explain the role of Genomics in Personalized Medicine.
19. Elaborate in details the attributes of QSAR.
20. Explain with neat illustrations the principles of micro
array techniques.