Exam Details
| Subject | organic chemistry – ii | |
| Paper | ||
| Exam / Course | b. pharmacy | |
| Department | ||
| Organization | solapur university | |
| Position | ||
| Exam Date | March, 2018 | |
| City, State | andhra pradesh, solapur |
Question Paper
B.Pharm. (Semester III) (CBCS) Examination, 2018
organic chemistry ii
Day and Date Tuesday, 8-5-2018 Max. Marks 70
Time 3.00 p.m. to 6.00 p.m.
I. Choose the most appropriate one from the following answers (1×15)
Most acidic among the following
RCOOH Cl CH2 COOH
ClCH2CH2COOH O2NCH2COOH
Least basic of the following is
R NH2 RCONH2 R3N R2NH
Acidity of carboxylic acids is due to
Inductive effect Resonance
Field effect All
Characteristic reaction of aldehydes is nucleophilic reaction.
Addition Substitution Elimination None
in organic amines leads to increased water solubility.
Acylation Salt formation
Alkylation Oxime formation
Cumene process is related to the preparation of
Amines Aldehydes Carboxylic acids Phenols
In rearrangement an o-alkyl phenol is obtained.
Fries Hoffmann Claisen None
Resonance energy in Benzene is
36 Kcal/mole 121 Kcal/mole
141 KJ/mole 36 KJ/mole
P.T.O.
Seatno.SetP
Set P
SLR-TA 22 *SLRTA22*
Naphthalene on reduction with Na and Ethanol yields
Dialin Tetralin Decalin None
10) Electrophilic aromatic substitution at position is preferred over other places in pyridine.
None 2 3 1
11) The correct starting material for preparing esters by Fischers method is
RCOOH RCOCI RCONH2 (RCO)2O
12) Choose correct for the following reaction
ArCOR R1 NH2
ArCONHR1 ArCONR1R
ArCOR ArC NR1R
13) Isoquinoline on reacting with n-Butyl Lithium yields
1-Butyl isoquinoline 2-Butyl isoquinoline
3-Butyl isoquinoline 4-Butyl-isoquinoline
14) Five-membered unsaturated heterocycles name ends with the suffix
ine ole icine epine
15) Nitration of 2-substituted Indoles yields derivatives.
4-nitro 3-nitro 5-nitro 8-nitro
II. Answer any five questions from the following
Describe how amines are prepared in the laboratory.
Explain with examples four reactions of ketones.
What is Nucleophilic Aromatic Substitution Write four NAS reactions of benzene.
Write two methods of preparation of Naphthalene.
Write three electrophilic aromatic substitution reactions of pyrrole and thiophene.
How are carboxylic acids prepared Explain.
Set P
*SLRTA22* SLR-TA 22
III. Answer any three questions from the following (10×3)
Explain in detail
MPV Reduction
Aldol condensation
What is electrophilic aromatic substitution Explain how it occurs in Benzene
with examples. Include the mechanism
too.
Write four reactions for each
Quinoline
Anthracene
What are special reactions of phenols Discuss any three along with
their uses. 5
Discuss the role of diazotization in synthetic organic chemistry. 5
organic chemistry ii
Day and Date Tuesday, 8-5-2018 Max. Marks 70
Time 3.00 p.m. to 6.00 p.m.
I. Choose the most appropriate one from the following answers (1×15)
Most acidic among the following
RCOOH Cl CH2 COOH
ClCH2CH2COOH O2NCH2COOH
Least basic of the following is
R NH2 RCONH2 R3N R2NH
Acidity of carboxylic acids is due to
Inductive effect Resonance
Field effect All
Characteristic reaction of aldehydes is nucleophilic reaction.
Addition Substitution Elimination None
in organic amines leads to increased water solubility.
Acylation Salt formation
Alkylation Oxime formation
Cumene process is related to the preparation of
Amines Aldehydes Carboxylic acids Phenols
In rearrangement an o-alkyl phenol is obtained.
Fries Hoffmann Claisen None
Resonance energy in Benzene is
36 Kcal/mole 121 Kcal/mole
141 KJ/mole 36 KJ/mole
P.T.O.
Seatno.SetP
Set P
SLR-TA 22 *SLRTA22*
Naphthalene on reduction with Na and Ethanol yields
Dialin Tetralin Decalin None
10) Electrophilic aromatic substitution at position is preferred over other places in pyridine.
None 2 3 1
11) The correct starting material for preparing esters by Fischers method is
RCOOH RCOCI RCONH2 (RCO)2O
12) Choose correct for the following reaction
ArCOR R1 NH2
ArCONHR1 ArCONR1R
ArCOR ArC NR1R
13) Isoquinoline on reacting with n-Butyl Lithium yields
1-Butyl isoquinoline 2-Butyl isoquinoline
3-Butyl isoquinoline 4-Butyl-isoquinoline
14) Five-membered unsaturated heterocycles name ends with the suffix
ine ole icine epine
15) Nitration of 2-substituted Indoles yields derivatives.
4-nitro 3-nitro 5-nitro 8-nitro
II. Answer any five questions from the following
Describe how amines are prepared in the laboratory.
Explain with examples four reactions of ketones.
What is Nucleophilic Aromatic Substitution Write four NAS reactions of benzene.
Write two methods of preparation of Naphthalene.
Write three electrophilic aromatic substitution reactions of pyrrole and thiophene.
How are carboxylic acids prepared Explain.
Set P
*SLRTA22* SLR-TA 22
III. Answer any three questions from the following (10×3)
Explain in detail
MPV Reduction
Aldol condensation
What is electrophilic aromatic substitution Explain how it occurs in Benzene
with examples. Include the mechanism
too.
Write four reactions for each
Quinoline
Anthracene
What are special reactions of phenols Discuss any three along with
their uses. 5
Discuss the role of diazotization in synthetic organic chemistry. 5
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Subjects
- anatomy, physiology and health education – i
- anatomy, physiology and health education – ii
- biochemistry
- biochemistry – i
- biochemistry – ii
- biopharmaceutics
- biotechnology
- clinical pharmacology
- herbal technology
- human anatomy and physiology – i
- human anatomy and physiology – ii
- medicinal chemistry – i
- medicinal chemistry – ii
- medicinal chemistry – iv
- microbiology
- modern dispensing and hospital pharmacy
- novel drug delivery systems
- organic chemistry – i
- organic chemistry – ii
- organic chemistry – iii
- pathophysiology (new cbcs)
- pathophysiology and clinical biochemistry – i
- pathophysiology and clinical biochemistry – ii
- pharmaceutical analysis – i
- pharmaceutical analysis – ii
- pharmaceutical analysis – iv
- pharmaceutical analysis – v
- pharmaceutical analysis – vi
- pharmaceutical busines management
- pharmaceutical engineering
- pharmaceutical enginering
- pharmaceutical inorganic chemistry
- pharmaceutical jurisprudence
- pharmaceutical microbiology
- pharmaceutical organic chemistry – ii
- pharmaceutical organic chemistry –i
- pharmaceutics – i (new cbcs)
- pharmaceutics – i (old-cbcs pattern)
- pharmaceutics – ii
- pharmaceutics – iii
- pharmaceutics – iv
- pharmacognosy – i
- pharmacognosy – ii
- pharmacognosy – iii
- pharmacology – i (new) (cbcs pattern)
- pharmacology – ii
- pharmacology – ii (cgpa pattern)
- pharmacology – iv
- physical pharmaceutics – i
- physical pharmacy – i
- physical pharmacy – ii
- sterile dosage forms