[LO 116] MAY 2019 Sub. Code: 2013
M.D. DEGREE EXAMINATION
BRANCH III PATHOLOGY
PAPER IV IMMUNOPATHOLOGY, HAEMATOLOGY, PRINCIPLES
AND APPLICATION TO TECHNOLOGICAL ADVANCES
IN LABORATORY SERVICES
Q.P. Code: 202013
Time Three Hours Maximum 100 Marks
I. Essay: x 15 30)
1. Define and classify Myelodysplastic syndrome. Discuss the
etiopathogenesis. Describe peripheral blood and bone marrow findings.
2. Discuss in detail the mechanism of Immunologically mediated diseases.
Write about Immune complex mediated hypersensitivity. Describe
transplant rejection.
II. Write Short Notes on: (10 x 5 50)
1. Stains used in cytology.
2. Cryoprecipitate.
3. Polymerase chain reaction.
4. Bethesda system of reporting for FNAC thyroid.
5. Burkitt lymphoma.
6. Sezary syndrome.
7. Cytospin.
8. Telepathology.
9. Immunology of leprosy.
10. Myelofibrosis.
III. Reasoning Out: x 5 20)
1. A 50 year old male presented with moderate splenomegaly, fever and
hailing from North East India. What is the probable peripheral smear and
Bone marrow finding? What is your diagnosis?
2. A 58 year old lady with complaints of low back pain, was found to have
multiple osteolytic lesions and anaemia. Bone marrow aspiration was
done. Serum electrophoresis was advised. Discuss the diagnostic criteria
and prognostic factors of this condition.
3. 2 years old child had severe anaemia with massive spleen. Peripheral
smear showed numerous target cells and microcytes with nucleated RBCs.
Discuss the etiopathogenesis of this condition.
4. A 10 year old boy presented with osteolytic lesion in the skull and skin
nodules. FNAC of the skin nodule showed plenty of eosinophils and
histiocytes. What is the probable diagnosis? Discuss the classification and
syndromes associated.

[LO 116]