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GENETICS

Roll
BOOKLET NO.

I I-I

Candidate should write his/her Roll No. In the box above Total No. of Questions: 150 Time: 2 Hours]
No. of Printed Pages 32 [Total Marks 300
I

INSTRUCTIONS FOR CANDIDATES
1.
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2.
All questions carry equal marks.


The question paper contains 150 questions. The examinee should verify that
the requisite number of questions are printed in the question paper. otherwise
he should ask for another question paper.
4.
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Read carefully the instructions given on the answer sheet supplied and indicate your answers accordingly.

6.
Kindly make necessary entries on the answer sheet only at the places indicated and nowhere else.

7.
Examinees should specially pay attention that 2 marks will be awarded for correct answer.

8.
Examinees should do all rough work on the space meant for rough work on the last page of the question paper and nowhere else, not even on the answer sheet.


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1. What is the nature of protoplasm?

Crystalline Compound


Colloidal Saturated solution


2. Who discovered the cell in section of cork

Leeuwenhoek Schleiden


Robert Brown Robert Hooke


3. Compound microscope contains how many lenses

2


4 1


4. Percentage of water in typical (plant) cell is

85% 50%


20% 10%


5. Which of the following occurs only in RNA

Adenine Cytosine


Guanine Uracil


6. Distance between two strands of DNA is

3.4A 34A


340 A 20A


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7.
One turn of DNA helix measures (Al 0.34 nm (Bl 3.4 nm (Cl 20 nm 34 nm

8.
One function of telomere in a chromosome is to (Al help two chromatids to move towards poles


start R.N.A. synthesis
(Cl seal the ends of chromosome



identify correct number of chromosomes



9.
Karyokinesis refers to the division of (Al Cytoplasm into two Nucleus into two (Cl Protoplasm into two None of these

10.
During meiosis the chromosome number is reduced to half at (Al Metaphase I (Bl Anaphase I (Cl Telophase I Telophase II

11.
Monohybrid test cross ratio comes as (Al1 1 11

12.
Improvement of mankind by genetic engineering is studied under


Eugenics Euthenics


Euphenics Pathology



13.
A pair of contrasting characters is represented by


Homozygous Heterozygous


Phenotype Allelomorphs



14.
A red flowered plant is crossed with white flowered plant and offsprings are pink this shows that gene R is


Mutant Recessive


Hybrid Incompletely dominant



15.
A cross between F1 and recessive parent IS


Reciprocal cross Monohybrid cross


Test cross Dihybrid cross



16.
One gene one enzyme theory was given by


Schleiden and Schwann Khorana and Nirenberg


Watson and Crick Beadle and Tatum



17.
Which is the true dihybrid condition


ttrr ttRr


TtRr Tt




1 (Cl1111 (Dl21
4

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18. How many types of gametes will be formed by the genotype individual AaBbCc (Al 16 (El8 (Cl 4 3
19.
Basic structural unit of eukaryotic chromosome IS (Al Chromatin fibre (Bl DNA (Cl Nucleosome Chromonema

20.
When a single gene influences more than one trait, it is called (Al Epistasis (El Pseudodominance (Cl Pleiotropy None of these

21.
Branch of science related with improvement of mankind genetics (Al Human genetics (El General genetics (Cl Eugenics Genetics

22.
The most commonly used enzyme for polymerase chain reaction is (Al DNA polymerase II (Bl Reverse transcriptase (Cl Klenow fragment Taq. Polymerase

23.
Genetically engineered bacteria have been successfully used in commercial production of


(Al Testosterone (El Thyroxine
(Cl Melatonin Human insulin

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24. GpneticaJ]y uniiCml1 population of an organism raised through tissue culture is called
(AJ Graft Clone
Ce) Plasmid Hybrid

2.5. Genetic engineering is also known as CA) somatic hybridization (El Gene manipulation
Protoplast technology Recombinant DNA technology
26. Biological scissors are

Ligases eE) Polymerases


Transcriptases Endonucleases


27. When foreign DNA is integrated with genome of virus acting as vector, which type of DNA is formed?

Recombinant DNA Chimeric DNA


Redundant DNA Copy DNA


28. Superbug was created by CA) Dilip Shah (El Robert Fraley
Anand Chakraborty CD) Hargobind Khorana
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29.
Each restriction enzyme cleaves a molecule at (Al End of genes (Bl Methyl group (Cl Time of DNA replication (Dl Particular nucleotide sequence

30.
Genes which confer antibiotic resistance on bacteria are located on (Al RNA (Bl Polysome (Cl Plasmid Chromosomal DNA

31.
Restriction enzymes are isolated chiefly from: (Al Algae (Bl Fungi (Cl Protozoans Prokaryote

32.
The prokaryotic genetic system has (Al DNA without histones (Bl DNA with Hstones (Cl Neither DNA nor histones Either yNA or histones

33.
Genetic engineering would not have been pos,ble if these were absent


(Al RNA synthetase JNA ligase (Cl DNA polymerase Reverse transcriptase
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34. The replication of D:A is

Conservative and continuous


Semiconservative and non-continuous


Semiconservative and semi-continuous


Semiconservative and continuous


35. Weismann gave which theory?

Continuity of germplasm Continuity of somatoplasm


Laws of heredity Theory of mutation


36. During elongation of polypeptide chain (in translation), the sigma factor

is released to again take part


is retained and performs special function


the function is unknown


used during the closing of chain


37. The parent. of 'Triticale' are:

Wheat ant rye Wheat and maIze


Barley and n.ize Barley and rye


38. Cell membrane is mace up of

Protein and lipid Protein, lipid and little DNA


Carbohydrates Proteins and cellulose




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39. Cytoplasmic bridge lined with a plasma membrane that connects adjacent cell IS

Protein Nerve


Steroids Plasmodesmata


40. Man-made crop IS (Al Triticum eEl Hordeum (Cl Raphallobrassica Eleusine
4l. Ribozyme is (Al Enzyme (El Protein (Cl Hormone CDl RNA having enzyme activity
42. t-RNA molecules have anticodons that pair complementary to the codons
III
(Al mRNA eE) rRNA
(Cl tRNA All of these

43. Which disease IS caused by activation of oncogenes (Al Viral f1u (El Tuberculosis
Cancer Cholera
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44. A micromutation is

Polyploidy Additions of chromosome


Change in gene Deletion of chromosome


45. The diameter of Z-DNA molecule is
18A eE) 34 A
45 A 22 A
46. A nucleoside is

Purine/Pyrimidine Sugar


Purine/Pyrimidine Phosphate


Sugar Phosphate


Purine/Pyrimidine Sugar Phosphate


47. The function of tRNA is

Selection of amino acids eE) Production of mRNA


Production of ribosomes CD) Production of microspores


48. A chemical mutagen is

X-ray


Dichloromethyl Urea (DCMU)


Gamma ray


Ethyl Methane Sulphonate


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49.
A gene showing codominance (Al has both alleles independently expressed (Bl has one allele dominant to other (Cl has alleles expressed at the same time (Dl has alleles that are recessive to each other

50.
Which component of transcribed RNA in eukaryotes is present in the initial transcript but is removed before translation occurs

(Al Intron (Bl poly A tail
(Cl Ribosome binding site cap


51.
Polyploidy refers to (Al extra copy of gene (Bl extra set of chromosomes (Cl the chromosome which has replicated but not divided (Dl multiple ribosomes on single mRNA

52.
What would be the frequency ofAABBCC individuals from mating two AaBbCc individuals

(Al 1/64 (Bl 1/32
(Cl 1/16 (Dl 3/16


53.
DNA ligase IS an enzyme (Al that joins fragments in DNA replication (Bl involved in protein synthesis (Cl which cuts DNA at defined sequences

that facilitates transcription

54.
An Hfr strain of E.coli contains


A bacterial chromosome with inserted human gene


A bacterial chromosome with inserted F factor


A human chromosome with transposable element


A bacterial chromosome with phage



55.
Colour blindness in man is


Due to deficiency of vitamin A


Due to absence of visual pupil in retina


Due to absence of rods in retina


A sex-linked abnormality



56.
The central dogma of protein synthesis IS gIVen by


Khorana Nathans


Crick Baltimore




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57. RFLP is a

Genetic signal Genetic code


Vector Genetic marker


58. DNA fingerprinting is a technique used in

Solving criminal and paternity cases


Reconstructing human relationships


Transfer of disease resistance to bone marrow


Estimating matches for blood transfusions


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59. PCR is a technique that

Demonstrates DNA as genetic material


Determines minerals in soil samples


Measures ribosome transfer rate


Replicates DNA sequences in-vitro


60. Majority of new mutations appear to be

beneficial


neutral or deleterious


detectable using allozyme studies


present within pericentric inversions


61. RNA molecules that exhibit catalytic activity are called

mRNAs ribonucleases


ribosomes ribozymes


62. Cellular proteins destined for secretion are sorted and packaged in the

Lysosomes Peroxisomes


Endoplasmic reticulum Trans Golgi network


63. An E.coli strain lacking DNA polymerase I would be deficient in DNA
repaIr (Bl splicing
(Cl degradatiC'n transcription

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64. Blood group B will have alleles
11 lAlA
lBlB 11 or lBlB
65. Which one is ineffective against antibiotics

Bacterial infected wound


Bacterial infected throat


Haemophilia


Bacterial infected gonorrhoea


66. Genetic code was given by

Watson and Crick


Nirenberg


Beadle and Tatum


Kings, Watson and Crick


67. Which of the following is genetically dominant in man?

Colour blindness Rh+


Haemophilia Albinism


68.
The stage of meiosis in which chromosomes pair and cross over is

69.
Mutations occurrmg m body cells are


Auxotrophic mutations Somatic mutations


Morphological mutations Sensitive mutations



70.
The phenomenon of 'independent assortment" is based on


Monohybrid cross Dihybrid cross


Trihybrid cross Back cross



71.
In Melandrium sex chromosomes form


Hemomorphic bivalent Zygomorphic bivalent


Heteromorphic bivalent Hyperactive bivalent



72.
Homeobox sequences


present in genome of many animal specIes


found in prokaryotes not in eukaryotes


represent integration sites for bacterial viruses


are integration sites for transposable elements



73.
Transcriptional activator proteins


transcribe a messenger off a DNA template


bind to ribosomes to activate proteins


produced during an infection of bacteria by phage


bind regions near eukaryotic gene




Prophase I Metaphase I
Prophase II Metaphase II
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74. Arabidopsis is advantageous for plant genetic research because (AJ it IS commercially important as food crop (BJ it IS an endangered speCIes (CJ it is closest to humans
it is small plant with a small genome SIze
75. A homeotic mutation is one which: (Al is present in <mly one form in an individual (EJ substitutes one body part for another in development (Cl results in development of a tumor
leads to increase body size in an organism
76. Plasmid vectors for cloning (AJ can accommodate larger inserts than phage vectors (EJ can grow within bacteria and are present on agar

can accommodate inserts over 100 kilobases


include centromeres to allow propagation in yeast


77. The "Sticky ends" allow: (AJ selection for plasmids (BJ identification of plasmids

replication of tRNA


pieces of DNA from different sources to hybridize


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78. :Iitochondrial is advantageous for evolutionary studies because

it IS inherited through female parent


it IS inserted into X-chromosome


it evolves more slowly than genes in nucleus


it was derived from globin genes as an extra copy


79. Twin studies in humans are useful because

they allow refind estimates of chromosome


they are heterozygous


allow improved expression of gene


establish interaction of heredity and environment


80. Alleles are

alternative forms of gene false forms of gene


extra forms of gene defective gene


81. The penetrance is

insertion of gene elimination of gene


ability of a gene to express incomplete expressIOn of gene


82. When one gene specifies more traits, it is

Pleiotropism Atavism


Polytropism Dwarfism


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83. Epistasis is

masking effect of one allele over other


masking effect of one gene over other


masking effect of one plant over other


masking of proteins


84. Lethal genes can

kill their bearers Handicap their bearers


kill the insects on plants kill the weeds


85. Sickle cell Anaemia is caused by

Pleiotropic gene Penetrant gene


Multiple alleles Lethal genes


86. Synapsis takes place at

Zygotene Diplotene


Pachytene Diakinesis


87. Xenia is

Masking effect of single dose of an allele over double dose of alternative allele


Masking effect of multiple dose of allele


masking effect of gene


masking effect of lethal alleles


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88. Seedless watermelons are

Autotetraploids Autotriploids


Autopentaploids Allopolyploids


89. Haploids have

Single set of genome


Double set of genome


Multiple set of genome


No genome


90. Which one of the following can behave as new species

Autopolyploids Allopolyploids


Autotriploids Autohexaploids


91. Double monosomy has a general formula
2n 2n
2n 2n-2-2
92. Klinefelter syndrome is the result of

Sex chromosomal abnormality


Autosomal abnormality


Genetic abnormality


Morphological abnormality


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93. The functional unit of gene IS

Muton Recon


Cistron Retron


94. Who discovered transposons

Hargobind Khorana Morgan


Hugo de Vries Barbara McClintock


95. Operon hypothesis was proposed by

Jacob and Monad Beadle and Tatum


Harshe and Chase Watson and Crick


96. Quantitative inheritance IS through

Defective genes Special genes


Polygenes illtragenes


97. Kappa particles are found in
Amoeba Ascaris
Daphnia Paramoecium
98. Shell coiling in snails is

Nuclear inheritance


Extra-nuclear inheritance


Cris cross inheritance


Mendelian inheritance


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99. Inbreeding refers to
Increase in homozygosity Increase m heterozygosity
Increase in fertility Increase in sterility
100. Exchanges between non-homologous sets of chromosomes are
Recombinations Inversions
Translocations Transductions
101. Point mutations are
Change in chromosome number
Change in chromosome structure
Change at DNA level
Change In nucleus
102. Transitions are:
Replacement of purines by purines
Replacement of purines by pyrimidines
Replacement of one gene by other
Replacement of one chromosome by other
103. Bacteria were first discovered by
Louis Pasteur A. Von Leeuwenhoek
Robert Koch Robert Hooke
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104. Bacteria differ from other plants in that they do not have
DNA RNA
Cell wall A well defined nucleus
105. Bacteria are considered to be the plants because they:
Have a rigid cell wall Cannot move
Are present everywhere Can multiply by fission
106. The shape of E.coli bacterium is
Rod Round
Spiral Fusiform
107. The cells of cyanobacteria and bacteria exhibit similarity in having
plastid nuclei
centrosome DNA
108. The bacterium used in natural genetic engineering is
Rhizobium Agrobacterium
Streptococcus Micrococcus
109. Bacteriophage consists of
Carbon and nitrogen DNA
Nucleoproteins Proteins only
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110. Genetic material of TMV is
DNA FAT
RNA None of these
111. Which part of the cell disappears during mitosis
Plastid Nucleolar membrane
Plasma membrane None of these
112. The technique of DNA fingerprinting was first developed by
Alec Jefferey Lal ji Singh
M.S. Swaminathan Barbara McClintock
113. Linkage was established by
Bridges Morgan
Mendel Erick
114. Complementary interaction of genes gives the ratio
13: 3 15: 1
7 1
115. Cells with abundant microvilli are found in
exocrine glands adipose tissue
neuronal dendrites absorptive epithelia

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116. Virus mediated transfer of genetic material IS
(Al induction (Bl transfection
(Cl transduction transposition
117. In operon concept, a repressor protein binds to
(Al an enhancer (Bl an operator
(Cl an AUG sequence (Dl a TATA box
118. In animals, enzyme ulllque to gluconeogenesis is
(Al enolase (Bl phosphoglyceromutase
(Cl aldolase (Dl fructose 6 bisphosphatase
119. Which one does /lot ·make direct use of a pH
(Al Mitochondrion (Bl Chloroplast
(Cl Protozoan cilium Bacterial flagellum
120. Which of the process does not occur in mitochondria of mammalian cell
(Al fatty acid biosynthesis (Bl protein synthesis
(Cl DNA synthesis citric acid .cycle
121. DNA transcribes to
(Al rRNA (Bl tRNA
(Cl mRNA hnRNA
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122. Which one of the following IS initiation codon?
AUG
AGA
123. Genetic code IS
Singlet
Triplet
124. Intelligence in man is
Polygenic trait
Congenital trait
125. Polydactyly refers to
5 fingers
more than five fingers
126. Rhizobium carries
nif genes
CIS genes

AGG UAA
Doublet Multilet
Mendelian trait Morphological trait
less than five fingers six fingers
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127. Geneticists associated with human genome project
(Al Creig Venter and Francis Collins
(Bl Kornberg and Thomas
(Cl Beadle and Tatum
CDl DeVries and Correns
128. Approximate number of genes m human diploid cell is
(Al 50 thousand 80 thousand
(Cl 30 thousand 20 thousand
129. B-chromosomes have got
Mendelian inheritance
Non-Mendelian inheritance
Polygenic inheritance
CD) Conventional type of inheritance
130. Aneuploidy arising through loss of chromosomes
Hypoploidy (El Nanoploidy
Lethoploidy Aploidy
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131. Ribosomes are the centres for
Fat synthesis Carbohydrate synthesis
Protein synthesis DNA synthesis
132. Human growth hormone is used for the treatment of
Hypopituitary dwarfism Hyperpituitary dwarfism
Defective growth Excess growth
133. Frequency of crossing over between two genes is directly proportionate to
Distance between genes
Distance between chromosomes
Distance between cells
Distance between cellular organelles
134. Unit used for determining genetic map distance
cm mm
plcogram morgan
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135. Bivalents are formed during
Mitosis Meiosis
Cytokinesis Karyokinesis
136. Ti-plasmid of Agrobacterium carnes
Terminator gene Tumour inducing gene
Transferred gene Tracer gene
137. When a wild type character is changed into mutant character, it IS
Forward mutation
Spontaneous mutation
Autosomal mutation
Sex-linked mutation
138. Apoptosis refers to

(Al cell elongation (Bl cell maturation
cell death cell division
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139. Tag-polymerase used III PCR IS obtained from
(Al Thermus aquaticus (Bl Bacillus thuringenesis
(Cl Pseudomonas scabies Vibrio choleri
140. Crossing over takes place at
(Al Diplotene (Bl Pachytene
(Cl Leptotene Zygotene
141. Mis-division of centromere gives rise to
Duplicated chromosome
Deficient chromosome
Isochromosomes
Giant chromosome
142. Meiotic division takes place in the cells of
Root tips Pollen mother cells
Stem tips Leaf tips
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143. The number of autosomes found in a diploid human cell is
48 23
44 40
144. Organized clathrin structures are associated with
nuclear envelop Lysosomes
extracellular matrix trans golgi network
145. Which hormone initiates biological actions by crossing the plasma membrane
and binding to a receptor
Glucagon Estradiol
Insulin Norepinephrine
146. Common lesions found in DNA exposed to UV light are:
pyrimidine dimers single strand breaks
base deletions purine dimers
147. Which bonds are least likely to be involved in stabilizing three-dimensional
folding of proteins
Hydrogen bonds Ester bonds
Disulfide bonds Electrostatic bonds
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148. Which enzyme IS involved III biosynthesis of collagen
Prolyl hydroxylasl­
Choline oxidase
Monoamine oxidase
Tryptophan oxygenase
149. The specialized structures located at the ends of eukaryotic chromosomes are called
terminators telomeres
centromeres kinetochores
150. All of the following compounds are capable of forming hydrogen bonds with water, except:
Methanol Acetamide
Methyl acetate Hexane
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