THE TAMIL NADU DR. M.G.R. MEDICAL UNIVERSITY
(LO 2033) MARCH 2019 Sub. Code: 2033
B.PHARM. DEGREE EXAMINATION
PCI Regulation SEMESTER III
PAPER II PHYSICAL PHARMACEUTICS I
Q.P. Code: 562033
Time: Three hours Maximum: 75 Marks
I. Elaborate on: Answer any TWO questions. x 10 20)
1. Explain briefly on distribution law and its limitations.
2. Explain the term surface tension interfacial phenomena. Write the different
methods used to measure surface tensions. Explain any two methods elaborately.
3. Explain various methods to analysis complexes.
II. Write notes on: Answer any SEVEN questions. x 5 35)
1. Diffusion principles in biological systems.
2. Principle behind the working of aerosols.
3. Difference between amorphous crystalline solids.
4. How the solubility of partially miscible liquids occurs and explains with one
example?
5. Different types of adsorption isotherms.
6. How micellar system solubilize the poorly soluble drugs?
7. Significance of protein binding.
8. Various methods to determine pH.
9. Methods to adjust isotonicity.
III. Short answers on: Answer ALL questions. (10 x 2 20)
1. Define spreading co-efficient.
2. Henry's law-define with equation.
3. HLB scale.
4. What do you mean by binary solution and give example?
5. Examples of pharmaceutical buffers.
6. What is the nature of solvent and cosolvent and give examples?
7. pH equation for acid and alkali.
8. Examples for biological buffers.
9. Write the different between hypotonic and hypertonic solution.
10. Write the equation for Fick's law of diffusion.