THE TAMIL NADU DR. M.G.R. MEDICAL UNIVERSITY
(LO 2016) MARCH 2019 Sub. Code: 2016
B.PHARM. DEGREE EXAMINATION
PCI Regulation SEMESTER II
PAPER II PHARMACEUTICAL ORGANIC CHEMISTRY I
Q.P. Code: 562016
Time: Three hours Maximum: 75 Marks
I. Elaborate on: Answer any TWO questions. x 10 20)
1. Discuss SN1 and SN2 reactions with special reference to mechanism reactivity and
stereochemistry.
2. What are alkyl halides? How will you prepare alkyl halides and aryl alkyl halides?
3. Explain the phenomenon of SP4 SP3 trigonal hybridization with suitable
example.
II. Write notes on: Answer any SEVEN questions. x 5 35)
1. What is Diazonium reaction? Explain the general reaction.
2. Explain the Markonnikoffs rule and peroxide effect.
3. What is Diel's Alder reaction? Explain with examples.
4. Write the method of preparation of ether by williamson's synthesis.
5. How chloroform is prepared industrially? Write the properties, analytical test and
uses of Chloroform.
6. Explain the formation of bonding, antibonding and nonbonding orbitals.
7. Give any three methods of preparation and three reactions of Amines.
8. Explain the photohalogenation and thermal halogenations of alkanes.
9. Explain any three methods of preparation of alcohols.
III. Short answers on: Answer ALL questions. (10 x 2 20)
1. Define and classify Carboxylic acids and Esters.
2. Define Ozonolysis with examples.
3. Wolf Kishner reduction.
4. What is hypercongucation?
5. Give the IUPAC name of HO-CH2-CH2-COOH
6. How is glycol synthesized?
7. Explain resonance effect.
8. Give the structure and use of amphetamine.
9. Write the structure and uses of cinnamaldehyde.
10. Write the structure and use of Benzyl Benzoate.