THE TAMIL NADU DR. M.G.R. MEDICAL UNIVERSITY
(LO 4267) FEBRUARY 2019 Sub. Code: 4267
B.PHARM. DEGREE EXAMINATION
FOURTH YEAR
PAPER I FORMULATIVE PHARMACY AND BIO-PHARMACEUTICS
Q.P. Code: 564267
Time: Three hours Maximum: 100 Marks
I. Elaborate on: x 20 40)
1. Write the advantages and limitation of prolonged action pharmaceuticals. Write
about two method of preparation and evaluation of prolonged action
pharmaceuticals.
2. Write the goals of pre-formulation studies. Explain the physical properties of
drugs in pre-formulation studies and their importance.
II. Write notes on: x 5 40)
1. Methods to enhance the solubility of poorly soluble drugs.
2. Microencapsulation by air suspension technique.
3. Dissolution testing.
4. Drug excipient compatibility studies.
5. Physico-chemical factors affecting drug absorption.
6. Evaluation of transdermal patches.
7. Filling of Hard capsules.
8. Accelerated stability studies.
III. Short answers on: (10 x 2 20)
1. Permeation enhancers.
2. Biopharmaceutics.
3. Partition co-efficient.
4. Polymorphism.
5. Various sizes of hard capsule.
6. Renal clearance.
7. Nanoparticles.
8. Bloom strength.
9. Elementary osmotic pump.
10. Organoleptic additives.