THE TAMIL NADU DR. M.G.R. MEDICAL UNIVERSITY
(LO 4271) FEBRUARY 2019 Sub. Code: 4271
B.PHARM. EXAMINATION
FOURTH YEAR
PAPER V MEDICINAL CHEMISTRY II
Q.P. Code 564271
Time: Three hours Maximum: 100 Marks
I. Elaborate on: x 20 40)
1. Define antineoplastic agents. Elaborate the classification, mechanism of action and
structures of various alkylating agents and antimetabolites. Also write the
synthesis of any three.
2. Write a detailed note on combinatorial chemistry.
Describe various techniques utilized in computer aided drug design.
II. Write notes on: x 5 40)
1. Enumerate the synthesis of chloroquine.
2. Write a detailed note on cardiotonics.
3. Write in detail about the SAR of azole anti-fungals.
4. Classify semisynthetic pencillins and write the advantages of semisynthetic
pencillins over natural pencillins.
5. Brief out a note on glucocorticoids.
6. Enumerate the synthesis and mechanism of action of amantadine.
7. Write a note on insulin and its preparations.
8. Write a note on lipophilic parameters and its application in drug design.
III. Short answers on: (10 x 2 20)
1. What is crystalluria and give the methods used to reduce crystalluria?
2. Write the synthesis of phenytoin.
3. Brief a note on the mechanism of action of ethionamide.
4. Write on angiotensin receptor antagonist.
5. Write the structure of ciprofloxacin and nitrofurantoin.
6. Write a short note on antithyroid drugs.
7. Write the medicinal importance of dihydropyridines.
8. Explain the structure and use of trimethoprim.
9. Define anti-pedicular agents.
10. Write a short note on benzimidazole anthelmintics.