Seat No.: Enrolment
GUJARAT TECHNOLOGICAL UNIVERSITY
M.PHARM SEMESTER EXAMINATION -WINTER 2018
Subject Code: MPT102T Date: 03/01/2019
Subject Name: Advances in drug delivery system
Time 10:30 AM TO 01:30 PM Total Marks: 80
Instructions:
1. Attempt any five questions.
2. Make Suitable assumptions wherever necessary.
3. Figures to the right indicate full marks.
Q.1

Discuss basic concepts of sustained and controlled drug delivery systems.
06

Give classification of oral controlled drug delivery systems.
05

Discus mechanism of drug delivery from SR/CR formulation.
05
Q.2

Discuss the suitable excipients for osmotic drug delivery system. Which API's can be formulated by this approach? Why?
06

Describe physic-chemical and biological factors influencing dissolution and diffusion controlled systems.
05

Describe criteria for the drug candidate selection for SR/CR dosage forms.
05
Q.3

List out the factors affecting the designing of oral sustained release drug delivery system and discuss any one in detail to formulate it.
06

Write a note on mucoadhesive drug delivery system.
05

Define microencapsulation. Mention objectives of microencapsulation.
05
Q.4

Enlist various approaches for the preparation of microcapsules. Explain any two.
06

Describe various evaluations of microcapsules.
05

Write a note on intra muscular implants.
05
Q.5

Define Implants and Inserts. Discuss the applications, techniques and mechanism of drug release for subcutaneous implants with examples.
06

Write a note on Intra vaginal Inserts.
05

Write a note on sonophoresis.
05
Q. 6

What are the approaches for formulation development of transdermal drug delivery systems? Explain in details.
06

Discuss physicochemical biological approaches for sustained release formulations.
05

Discuss percutaneous absorption through skin.
05
Q.7

Discuss 3D printing of pharmaceuticals and telepharmacy.
06

Describe various evaluation parameters of Transdermal drug delivery systems.
05

Write a note on personalized medicine.
05