Seat No.: Enrolment
GUJARAT TECHNOLOGICAL UNIVERSITY
M.PHARM SEMESTER EXAMINATION -WINTER 2018
Subject Code: MPL103T Date: 05/01/2019
Subject Name: Pharmacological and Toxicological Screening Methods-I
Time :10:30 AM TO 01:30 PM Total Marks: 80
Instructions:
1. Attempt any five questions.
2. Make Suitable assumptions wherever necessary.
3. Figures to the right indicate full marks.
Q.1

Write a note on transgenic animals.
06

Write description, handling and applications of any two laboratory animals.
05

Describe the techniques used for anaesthesia and euthanasia of experimental animals.
05
Q.2

Describe different animal models for the evaluation of anxiolytic activity.
06

Discuss the principle and use of following equipment in evaluating activity
of drugs and name the class of drug for which it is used
Electroconvulsiometer
Cook's Pole Climbing Apparatus
05

Classify models for evaluation of parasympatholytic drugs and discuss any one in detail.
05
Q.3

Write briefly in-vivo methods to evaluate anti-asthmatic drugs.
06

Enlist various in vivo methods for screening of anti-inflammatory agents. Explain any two in brief.
05

Discuss Chemical and Thermal methods for screening of analgesic drugs.
05
Q.4

Enlist the different models for evaluation of Peptic ulcer. Describe any one in detail.
06

Describe methods to screen anti-fertility agents used in women.
05

Describe any three methods for evaluation of activity of coronary vasodilator
drugs.
05
Q.5

Explain the methods for biological evaluation of drugs used in atherosclerosis.
06

Enlist the methods used for inducing Diabetes in experimental animals. Explain methods for screening oral hypoglycemic agents.
05

Give the limitations of animal experimentation. Write briefly about alternate animal experiments.
05
Q. 6

Describe the general principles of immunoassay.
06

Enlist the hepatoprotective screening methods. Explain any two in detail.
05

Enlist various methods for screening drugs acting on adrenergic system.
05
Q.7

Enumerate various models for screening of antiparkinsonian drugs. Explain any one model in detail.
06

Describe the various methods for Bioassay with examples.
05

How diuretic activity can be studied using rats? Explain model briefly.
05