Seat No.: Enrolment
GUJARAT TECHNOLOGICAL UNIVERSITY
M.PHARM SEMESTER EXAMINATION -WINTER 2018
Subject Code: MPL102T Date: 03/01/2019
Subject Name: Advanced Pharmacology-I
Time :10:30 AM TO 01:30 PM Total Marks: 80
Instructions:
1. Attempt any five questions.
2. Make Suitable assumptions wherever necessary.
3. Figures to the right indicate full marks.
Q.1

Write in detail synthesis, storage, release and metabolism of adrenaline and drugs affecting each of these pathways.
06

Explain renal elimination of drugs.
05

Write in detail dopaminergic pathways in CNS and its functions.
05
Q.2

Write pharmacology of local anesthetic agents.
06

Write a note on significance of protein binding.
05

Compare and contrast Benzodiazepines and Barbiturates.
05
Q.3

Write short note on newer antiepileptic agents.
06

Explain dose response relationship with suitable illustrations.
05

Justify the use of calcium channel blockers as antihypertensive, antianginal and antiarrhythmic agent.
05
Q.4

Write shortnote on opioid antagonists.
06

Describe the management of Parkinson's Disease.
05

Classify lipid lowering agents. Write a note on newer therapies for management of dyslipidemias.
05
Q.5

Write physiological and pathological role of Serotonin.
06

Write short note on drugs affecting neuromuscular junction.
05

Write advances in treatment of depression.
05
Q. 6

What is monday morning sickness? Write pharmacology of Nitrates.
06

Describe the role of excitatory neurotransmitters in neurodegenerative diseases.
05

Write a note on anticholinesterases.
05
Q.7

Explain in detail the factors affecting drug absorption with examples.
06

Write a note on enzyme induction and enzyme inhibition with examples.
05

Classify NSAIDS. Write pharmacology of Aspirin.
05