Seat No.: Enrolment
GUJARAT TECHNOLOGICAL UNIVERSITY
M.PHARM SEMESTER EXAMINATION -WINTER 2018
Subject Code: MPC104T Date: 07/01/2019
Subject Name: Chemistry of Natural Products
Time :10:30 AM TO 01:30 PM Total Marks: 80
Instructions:
1. Attempt any five questions.
2. Make Suitable assumptions wherever necessary.
3. Figures to the right indicate full marks.
Q.1

How methadone is discovered taking morphine as lead molecule?
06

Give chemistry of cephalosporins.
05

Write genesis of antimalarial agents.
05
Q.2

What are alkaloids? Discuss steps involved in determination of molecular structure of alkaloids.
06

Discuss the chemistry of morphine.
05

Write chemistry of contraceptive agents.
05
Q.3

Give stereochemistry of steroids.
06

Give probable IR peaks in Digoxin and penicillin.
05

Give principle of DNA and RNA estimation.
05
Q.4

Write a note on oligonucleotide therapy.
06

Write probable 1H and 13C NMR signals ppm) of Quercetin and camphor.
05

Give chemical constituents and uses of Salacia reticulate and Swertia chirata.
05
Q.5

Give recent advances of gene therapy.
06

Write mass fragmentation pattern of any two natural products.
05

Describe active constituents of any one natural antitumor drug.
05
Q. 6

Give chemistry and physiological importance of Vitamin C and E.
06

Give structure elucidation and importance of menthol.
05

Classify terpenoids with examples. What is isoprene rule?
05
Q.7

Give isolation and purification of flavonoids.
06

Write a note on neuromuscular junction blocking agents.
05

Give nomenclature of steroids.
05