Seat No.: Enrolment
GUJARAT TECHNOLOGICAL UNIVERSITY
M.PHARM SEMESTER EXAMINATION -WINTER 2018
Subject Code: MPH201T Date: 15/11/2018
Subject Name: Molecular Pharmaceutics(Nano Tech and Targeted DDS)
Time :02:30 PM TO 05:30 PM Total Marks: 80
Instructions:
1. Attempt any five questions.
2. Make Suitable assumptions wherever necessary.
3. Figures to the right indicate full marks.
Q.1

Define: Targeted drug delivery systems. Explain different types of drug targeting.
06

Define Niosomes, Liposomes, Aquasomes, Phytosomes, Electrosomes.
05

Enlist methods of preparing Niosomes. Discuss any one in detail
05
Q.2

Explain in detail the method of producing monoclonal antibodies by hybridoma technology.
06

Describe in brief the applications of monoclonal antibodies.
05

Explain advantages of intranasal route of administration. Discuss factors affecting permeability of drugs through nasal mucosa
05
Q.3

Describe strategies for brain specific drug delivery.
06

What is the role of propellant in Aerosols? Discuss about types of propellants
05

What approaches can be used for tumor drug targeting?
05
Q.4

Define: Gene Therapy. Describe ex vivo and in vivo gene therapy
06

Describe the types of vectors used in gene therapy
05

Write a note on liposomal gene delivery systems.
05
Q.5

Differentiate between Microspheres and nanoparticles. Enlist methods of preparing nanoparticles.
06

Describe the evaluation parameters for nanoparticles.
05

Write a note on polymers used for preparing microspheres.
05
Q. 6

Enumerate methods of preparing microspheres. Discuss any one in detail.
06

Describe the evaluation parameters for microspheres
05

Describe the formulation of nasal sprays. How is it evaluated?
05
Q.7

Write a note on antisense molecules and Aptamers.
06

Describe containers for aerosols.
05

How are Phytosomes formulated?
05