Exam Details
| Subject | advanced biopharmaceutics & pharmacokinetics | |
| Paper | ||
| Exam / Course | mca | |
| Department | ||
| Organization | Gujarat Technological University | |
| Position | ||
| Exam Date | November, 2018 | |
| City, State | gujarat, ahmedabad |
Question Paper
Seat No.: Enrolment
GUJARAT TECHNOLOGICAL UNIVERSITY
M.PHARM SEMESTER EXAMINATION -WINTER 2018
Subject Code: MPH202T Date: 17/11/2018
Subject Name: Advanced Biopharmaceutics Pharmacokinetics
Time :02:30 PM TO 05:30 PM Total Marks: 80
Instructions:
1. Attempt any five questions.
2. Make Suitable assumptions wherever necessary.
3. Figures to the right indicate full marks.
Q.1
Discuss the diffusion-layer theory using Noyes-Whitney's equation and the variables that influence drug dissolution.
06
Discuss compendial methods of dissolution.
05
Write note on statistical methods for comparison of dissolution profiles.
05
Q.2
How is in-vitro and in-vivo correlation established? Explain levels of IVIVC.
06
Discuss the dosage form factors affecting drug absorption.
05
Write a note on pH-partition theory.
05
Q.3
Explain the term "compartment". What are the assumptions made in compartment modelling? Discuss the advantages and disadvantages of compartment modelling.
06
What are pharmacokinetic models? Discuss the importance and types of such models.
05
Explain Wagner-nelson method for determination of absorption rate constant(Ka).
05
Q.4
What is purpose of bioavailability testing? Elaborate the various methods of assessing bioavailability.
06
Define nonequivalence. Discuss the experimental design of single dose bioequivalence study of any dosage form.
05
Discuss protein binding of drugs and how it affects drug distribution.
05
Q.5
Explain pharmacokinetic and pharmacodynamics characteristics essential for a drug in the design of controlled release products.
06
Write a note on Pharmacokinetics and pharmacodynamics of biotechnology drugs.
05
Write a note on drug transporters.
05
Q. 6
Discus the one compartment open model for drug administered as continuous I.V. infusion.
06
Define pharmacokinetic and pharmacodynamic drug interactions. Give examples of beneficial drug interactions.
05
Discuss various drug transport mechanisms.
05
Q.7
Define bioequivalence and list the various methods involved in determination of bioequivalence.
06
What are the biopharmaceutic characteristics of a drug to be taken into consideration in designing controlled release formulations?
05
Elaborate on dissolution test parameters affecting drug dissolution.
05
GUJARAT TECHNOLOGICAL UNIVERSITY
M.PHARM SEMESTER EXAMINATION -WINTER 2018
Subject Code: MPH202T Date: 17/11/2018
Subject Name: Advanced Biopharmaceutics Pharmacokinetics
Time :02:30 PM TO 05:30 PM Total Marks: 80
Instructions:
1. Attempt any five questions.
2. Make Suitable assumptions wherever necessary.
3. Figures to the right indicate full marks.
Q.1
Discuss the diffusion-layer theory using Noyes-Whitney's equation and the variables that influence drug dissolution.
06
Discuss compendial methods of dissolution.
05
Write note on statistical methods for comparison of dissolution profiles.
05
Q.2
How is in-vitro and in-vivo correlation established? Explain levels of IVIVC.
06
Discuss the dosage form factors affecting drug absorption.
05
Write a note on pH-partition theory.
05
Q.3
Explain the term "compartment". What are the assumptions made in compartment modelling? Discuss the advantages and disadvantages of compartment modelling.
06
What are pharmacokinetic models? Discuss the importance and types of such models.
05
Explain Wagner-nelson method for determination of absorption rate constant(Ka).
05
Q.4
What is purpose of bioavailability testing? Elaborate the various methods of assessing bioavailability.
06
Define nonequivalence. Discuss the experimental design of single dose bioequivalence study of any dosage form.
05
Discuss protein binding of drugs and how it affects drug distribution.
05
Q.5
Explain pharmacokinetic and pharmacodynamics characteristics essential for a drug in the design of controlled release products.
06
Write a note on Pharmacokinetics and pharmacodynamics of biotechnology drugs.
05
Write a note on drug transporters.
05
Q. 6
Discus the one compartment open model for drug administered as continuous I.V. infusion.
06
Define pharmacokinetic and pharmacodynamic drug interactions. Give examples of beneficial drug interactions.
05
Discuss various drug transport mechanisms.
05
Q.7
Define bioequivalence and list the various methods involved in determination of bioequivalence.
06
What are the biopharmaceutic characteristics of a drug to be taken into consideration in designing controlled release formulations?
05
Elaborate on dissolution test parameters affecting drug dissolution.
05
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