FACULTY OF PHARMACY
B. Pharmacy IV-Year II-Semester (Main) Examination, April 2016
Subject Pharmacoinformatics
Time 3 Hours Max. Marks: 70
Note: Answer all questions. All questions carry equal marks.
1 Write briefly about database normalization and database architecture.
Write about Drug Information databases.
OR
What is Phylogenetic analysis? Write about methods of Phylogenetic analysis.
Write about Cood's Rules.
2 What is sequence alignment? Explain algorithms for sequence alignment.
Write a short note on Search machines and Complex searching.
OR
Explain briefly about
Database querying
Key work searching
Write about Bio-Perl.
3 Describe in detail about the Drug information services and resources available.
Write a short note on critical evaluation of drug information and literature.
OR
Write about emergency treatment of poisoning.
What is pharmacy automation? Explain applications of automation in medication
dosage, distribution, management and inventory control.
4 What are the biological databases? Explain Swissprot, Pfam and PDB of protein
databases.
Write short note on BLAST.
OR
What are the biological databases? Explain protein databases
Swissprot Pfam CATH PDB
5 Write differences between SAR and QSAR. Explain Free-Wilson analysis for drug
design.
Write a brief note on factors affecting on bioactivity of drugs.
OR
What are the theories for drug receptor interactions? Write briefly about factors
affecting on drug receptor interactions.
Write a short note on Energy minimization Docking