FACULTY OF PHARMACY
M. Pharmacy (Pharm. Chemistry) II-Semester (Main) Examination,
August 2018
Subject Advanced Organic Chemistry-II
Time: 3 Hours Max. Marks: 75
Note: Answer any five questions. All questions carry equal marks.
1 Discuss the basic Principles of green chemistry
Discuss the merits, demerits and any five applications of micro wave assisted
reactions.
2 What are pericyclic reactions? Discuss Cycloaddition and electrocyclic reactions
in presence of heat and photo light with mechanism and stereochemistry.
3. What is homogenous and heterogonous catalysis? Explain advantages and
disadvantages. Discuss examples of drug syntheses involving Wilkinson catalyst
and Ziegler Natra catalyst (one each)
Discuss the theory and applications of phase transfer catalysts
4. Discuss different methods of asymmetric synthesis with suitable examples
5 Explain the basic principles of solid phase peptide synthesis. Write about solid
supports, linkers, protecting and de protecting groups used in solid phase peptide
synthesis
6. Discuss any five synthetic applications of Ultra sound assisted reactions
Discuss sequential strategies in solution phase peptide synthesis with two case
studies
7. Explain Cahn, Ingold, Prelog sequence rules with suitable examples
Discuss cis-trans isomerism in cyclic and double bond containing compounds
8. Write a note on:
Photo-oxidation reactions
Sigmatropic reactions
Bio catalysts