BIO/VI/12 Student's Copy
2 0 1 8
6th Semester
BIOTECHNOLOGY
Paper BT-XII
Medical Biotechnology
Full Marks 55
Time 2½ hours
PART A—OBJECTIVE
Marks 20
The figures in the margin indicate full marks for the questions
SECTION—A
Marks 5
Tick the correct answer in the brackets provided 1×5=5
1. Production of human growth hormone was first done using recombinant
DNA technology in which of the following organisms?
Bacillus subtilis
E. coli
Helicobacter pylori
Mycobacterium
/528 1 Contd.
2. Which of the following is/are used for jet injection of therapeutic gene
inside the cell?
Electrical currents
Ultrasonic waves
High pressurized gas
Hydrostatic pressure
3. Hybridoma technology was developed by
Köhler and Milstein
Khorana and Nirenberg
Khorana and Korenberg
Beadle and Tatum
4. An ex-vivo approach for whole organ replacement is
substitutive approach
histioconductive approach
histioinductive approach
None of the above
5. Prenatal diagnosis at 16 weeks of pregnancy can be performed using all
of the following except
amniotic fluid
maternal blood
chorionic villi
fetal blood
BIO/VI/12 2 Contd.
SECTION—B
Marks 15
Write short notes on the following 3×5=15
1. Ex-vivo and in-vivo gene therapies
2. Principles of gene therapy
3. Toxoid vaccines
4. Cadaver skin
5. Ultrasonography
PART B—DESCRIPTIVE
Marks 35
The figures in the margin indicate full marks for the questions
1. What are the main aims of medical biotechnology research? Discuss the
major contributions of medical biotechnology research to the field of
pharmacology.
OR
Write notes on the major strategies and techniques involved in gene
therapy. 7
2. Give a detailed account on the construction and working of adenovirus
vectors. 7
OR
Briefly explain the various non-viral gene delivery methods. State its
advantages over viral delivery method.
BIO/VI/12 3 Contd.
3. Write a note on vaccines. 7
OR
Describe hybridoma technology in detail.
4. Mention the different kinds of bioengineered skin substitutes. Explain with
examples. 7
OR
Write a note on the ethical issues involved in organ transplantation in
human beings.
5. Describe the different invasive methods employed in prenatal testing. 7
OR
Describe the general concepts of genetic screening.