FINAL EXAM NATIONAL BOARD OF EXAMINATIONS
DECEMBER 2016
POSSESSION USE OF CELL PHONES OR ANY SUCH ELECTRONIC GADGETS IS NOT PERMITTED INSIDE THE
EXAMINATION HALL.
IMMUNO-HEMATOLOGY TRANSFUSION MEDICINE
PAPER I
IHTM/D/16/15/I
Time 3 hours
Max. Marks 100
Important instructions:
• Attempt all questions in order.
• Each question carries 10 marks.
• Read the question carefully and answer to the point neatly and legibly.
• Do not leave any blank pages between two answers.
• Indicate the question number correctly for the answer in the margin space.
• Answer all the parts of a single question together.
• Start the answer to a question on a fresh page or leave adequate space between two answers.
• Draw table/diagrams/flowcharts wherever appropriate.
Write short notes on:

1. Prothrombin time Clinical utilities.
Explain International Normalized Ratio.
4+6
2. Coulter principle.
Optical platelet count.
Immature platelet fraction.

3. Graft versus host disease (GvHD).
Differentiate Transfusion from Transplant related GvHD
including management and prevention.
3+7
4. Define stem cells.
Hierarchy of Stem cells and iPS (induced Pluripotent Stem
cell).
Haematopoiesis from a pluripotent stem cell.

5. ADAMTS 13.
Thrombotic thrombocytopenic purpura.
4+6
6. Structure of Globin chain genes.
Haemoglobin synthesis.
5+5
7. Bleeding assessment tools.
10
8. Chromatography and Haemoglobin.
Hb Variant analysis.
5+5
9. Vitamin B12 metabolism.
Pernicious anemia.
5+5
10. ABO blood group system.
Molecular basis of A2 sub-group.
5+5