FINAL EXAM NATIONAL BOARD OF EXAMINATIONS
DECEMBER 2017

POSSESSION/USE OF CELL PHONES OR ANY SUCH ELECTRONIC GADGETS IS NOT PERMITTED INSIDE THE EXAMINATION HALL.
IMMUNO-HEMATOLOGY TRANSFUSION MEDICINE
PAPER-IV
IHTM/D/17/15 /IV
TIME 3 HOURS
MAX. MARKS 100
• Attempt all questions in order.
• Each question carries 10 marks.
• Read the question carefully and answer to the point neatly and legibly.
• Do not leave any blank pages between two answers.
• Indicate the question number correctly for the answer in the margin space
• Answer all the parts of a single question together.
• Start the question to a question on a fresh page or leave adequate space between two answers.
• Draw table/diagrams/flowcharts wherever appropriate.
Write Short notes on:
1. a. Chimeric Antigen Receptor T cell
b. Discuss CAR-T cell therapy
5+5
2. a. Principle of Extra corporeal photopheresis
b. Discuss its clinical applications
5+5
3. a. Define micro-chimerism
b. Describe methods of detection of micro chimerism
c. Discuss significance in organ transplantation

4. Describe various assays to test hemolytic potential of red cell
alloantibodies.
10
5. a. What is "Residual Risk" in relation to microbiological screening of the
blood supply?
b. Describe various measures which may be taken to reduce the residual
risk of transfusion transmitted infections in India.
3+7
6. Discuss applications of molecular typing of blood group antigens.
10
7. a. Discuss rationale and indications of red cell exchange in Sickle cell
disease
b. Discuss transfusion support in a patient with Sickle cell disease
5+5
8. a. Stem cell plasticity
b. Induced pluripotent stem cells.
5+5
9. a. Minor ABO incompatible Bone Marrow/ peripheral blood stem cell
transplant
b. Enumerate complications
c. Management of complications and transfusion support

10. a. "Near Miss Events"
b. Discuss causes and prevention of Near Miss Events
3+7