FINAL EXAM NATIONAL BOARD OF EXAMINATIONS
JUNE 2018

POSSESSION/USE OF CELL PHONES OR ANY SUCH ELECTRONIC GADGETS IS NOT PERMITTED INSIDE THE EXAMINATION HALL.
HEMATOLOGY
PAPER-II
HEMAT/J/18/48/II
Time: 3 hours
Max. Marks:100
IMPORTANT INSTRUCTIONS
Attempt all questions in order.
Each question carries 10 marks.
Read the question carefully and answer to the point neatly and legibly.
Do not leave any blank pages between two answers.
Indicate the question number correctly for the answer in the margin space
Answer all the parts of a single question together.
Start the answer to a question on a fresh page or leave adequate space between two answers.
Draw table/diagrams/flowcharts wherever appropriate.
Write short notes on:
1. Waldenstrom macroglobulinemia:
Describe the pathogenesis and clinical presentation.
Describe the molecular pathology.
Outline the management.

2. Mast cell disorders:
Enumerate the conditions included in the WHO
Classification.
Diagnostic algorithm of mast cell proliferation including
molecular testing.
5+5
3. Plasmapheresis:
Describe the procedure.
Which are the hematological conditions where this
procedure is used?
5+5
4. Transfusion reactions:
Describe the clinical presentation of an acute transfusion
reaction.
How do we evaluate the cause of transfusion reaction?
Management protocol of patient with acute transfusion
reaction.

5. Hemophagocytic lymphohistiocytosis
What are the diagnostic criteria and investigations required?
Which are the clinical condition which are associated?
Outline the management.

6. Approach to a patient with massive splenomegaly:
Enumerate benign and malignant disorders.
Describe the diagnostic algorithm in a child versus an
elderly patient.
5+5
7. Hairy cell leukemia:
Describe the clinical and hematological findings.
Describe the management and follow up strategy.
5+5
P.T.O.
FINAL EXAM NATIONAL BOARD OF EXAMINATIONS
JUNE 2018

POSSESSION/USE OF CELL PHONES OR ANY SUCH ELECTRONIC GADGETS IS NOT PERMITTED INSIDE THE EXAMINATION HALL.
8. BRAF mutations:
Which are the conditions where the molecular defect can be
encountered?
Describe the diagnostic methodologies which can be used.
5+5
9. Graft versus host disease
What are the differences between acute and chronic
GVHD?
How do we grade GVHD?
Outline the management of GVHD.

10. Platelet transfusions:
What are the precautions exercised while processing blood
for platelet storage?
What are the clinical conditions where platelets are
transfused?
5+5