FINAL EXAM NATIONAL BOARD OF EXAMINATIONS
DECEMBER 2017

POSSESSION USE OF CELL PHONES OR ANY SUCH ELECTRONIC GADGETS IS NOT PERMITTED INSIDE THE
EXAMINATION HALL.
ENDOCRINOLOGY
PAPER III
Time 3 hours ENDO/D/17/07/III
Max. Marks 100
Important instructions:
• Attempt all questions in order.
• Each question carries 10 marks.
• Read the question carefully and answer to the point neatly and legibly.
• Do not leave any blank pages between two answers.
• Indicate the question number correctly for the answer in the margin space.
• Answer all the parts of a single question together.
• Start the answer to a question on a fresh page or leave adequate space between two
answers.
• Draw table/diagrams/flowcharts wherever appropriate.
Write short notes on:
1. Salient features of CANVAS and CANVAS-R trials.
5+5
2. Role of tyrosine kinase inhibitors in treatment of pituitary
tumours.
10
3. Genetic causes of isolated and combined pituitary
hormone deficiency.
5+5
4. New insulins, new combinations and smart insulins.

5. Approach to a patient with recurrent hypoglycemia with
no history of diabetes.
10
6. Describe PCSK9 monoclonal antibodies and statin
intolerance.
6+4
7. Evaluation and treatment of women with hirsutism and
androgenic alopecia.
10
8. Role of renin and prorenin in heart failure and cardiorenal
cross-talk.
10
9. Adenosine signaling in diabetes mellitus patho
physiology and therapeutic considerations.
5+5
10. Effect of alcohol on the endocrine system.
10