B.Pharmacy (Semester VII) Examination, 2017
PHARMACOLOGY III
Day and Date Tuesday, 16-5-2017 Total Marks 80
Time 3.00 p.m. to 6.00 p.m.
Instructions Solve all questions.
Marks of each questions are given on the right side in the
bracket.
1. Multiple Choice Questions (16×1=16)
Ethosuximide 1
By direct blockade of activated state of sodium channel
By indirect action of prolongation of inactivated state of sodium channel
By reducing low threshold T-type Ca2+ channel
By direct blockade of activated sodium and calcium channel
Picrotoxin is 1
GABAA antagonist Benzodiazepine antagonist
Dopamine D2 antagonist Barbiturate antagonist
Constipation and respiratory depression produced by morphine is mediated by 1
Kappa receptor 1 receptor
Delta receptor 2 receptor
Chimeric anti-TNF-α monoclonal antibody 1
Dalcizumab Infliximab
Muromonab-CD3 Adaliximab
Interleukin inhibits the activation of cytokine production by TH1 cells. 1
IL-2 IL-4
IL-6 IL-10
The NSAID used to treat primary dysammenorrhea. 1
Sulindac Ketoprofen
Tolmetin Meclofenamic acid
The drug binds to mammalian Target of Rapamycin (mTOR). 1
Mycophenolate mofotil Leflunomide
Sirolimus Sulindac
Antiseizure drug used to treat Lennox-Gastaut syndrome. 1
Tiagabine Primidone
Lamotrigine Carbamazepine
COMT-inhibitor 1
Phenelzine Tolcapone
Selegiline Ropinirole
10) Narcotic analgesic used to treat diarrhea 1
Meperidine Pentazocine
Loperamide Tremadol
11) Antipsychotic drug used to treat short term insomnia. 1
Loxapine Pimozide
Clozapine Zolpidem
12) Concentration of nitrous oxide required to produce "analgesia". 1
60% 20%
80% 30%
13) The drug inhibits the enzyme "aldehyde dehydrogenase". 1
Tolcapone Allopurinol
Disulfiram Selegiline
14) The drug acts by activation of PPAR- γ 1
Eparlestat Miglitol
Rosiglitazone Exenatide
15) The drug of choice to treat "Graves disease". 1
Radio active iodine Propylthiouracil
Methimazole Potassium perchlorate
16) The drug is used to treat paracetamol poisoning. 1
Naltrexone N-acetyl cystine
Theophylline Flummazenil
2. Answer any two questions out of three.
Classify oral hypoglycaemic agents with examples.
ii) Write mechanism of action, adverse effects and therapeutic uses of
"sulphonyl urea".
Write on various depressive disorders.
ii) Classify antidepressants with examples.
iii) Write mechanism of action of SNRI.
Define sedatives and hypnotics.
ii) Classify sedative and hypnotic with examples.
iii) Write mechanism of action of barbiturates.
3. Answer any two questions out of three.
Classify narcotic analgesics with examples.
ii) Write pharmacological effects of morphine on CNS CVS and
respiration.
iii) Write adverse effects of morphine.
Write on thyroid hormone biosynthesis.
ii) Classify antithyroid agents with examples.
iii) Write mechanism of action, merits and demerits of "radioactive iodine".
Describe Parkinson's disease.
ii) Classify drugs used to treat Parkinson disease.
iii) Write on Levo-Dopa-Carbidopa combination.
4. Answer any four questions out of five.
What is balanced anesthesia Describe various stages of anesthesia.
Write mechanism of action, adverse effects and therapeutic uses of Disulfiram.
Describe innate and adaptive immune system.
Write on immunosuppressive action and therapeutic uses of "Calcineurin
inhibitor".
Explain drug interactions
TCA MAO inhibitor.
ii) Barbiturate Vitamin K.
Explain the reasonings
Why nitrous oxide is not used as a sole agent as a general anaesthetic
ii) Why Salicylate is avoided in third trimester of pregnancy
5. Answer any four questions out of five.
What is cognitive enhancer Write pharmacology of "Piracetam".
Explain role of PTH and Vitamin D in calcium regulation.
Write on Allopurinol, its mechanism, adverse effects and therapeutic uses.
Describe the mechanism of action of Benzodiazepines and explain why
benzodiazepines is not used as a true general anesthetics
Write on Insulin receptor and its function in controlling glucose level.