M.Sc. (Semester II) (CBCS) Examination, 2017
GENETICS
COMPUTATIONAL STRUCTURE BIOLOGY AND DRUG DESIGNING
Day Date: Friday, 28-04-2017 Max. Marks: 70
Time: 10.30 AM to 01.00 PM
N.B. Part-I, Question 1 is compulsory.
Attempt any four questions from Part II.
Figures to the right indicate full marks.
Answer to the Part-I and Part-II are to be written in same
answer Booklet only.
Part-I
Q.1 Rewrite the sentence after choosing the correct answer from the
given alternatives
07
Homology modeling is also called as modeling.
Comparative Secondary Primary Domain
Proteomics is the study of
Set of proteins in a specific region of the cell Set of proteins
Entire set of expressed proteins in a cell None of these
Model can be evaluating by
Procheck ANOLEA WHAT IF All of these
Protein-Protein interaction prediction database are
DIP MINT STRING All of these
is the method used to design the drug using the knowledge
of 3D structure of protein.
Ligand based drug design Structure based drug design
Both a and b None of these
is visualization tool which does not recognize PDB format.
Cn3D RasMol RasTop PyMol
Molecular chemical structures can be designed using tools.
ACD Lab Chem sketch
KEGG draw All of the above
Definitions: 07
Prodrug
RCSB PDB
CYP450
SCOP
HTS
Domain
Lectin
Page 1 of 2
Part II
Answer any four of the following:
Q.2 What is yeast two hybrid system? Explain the mechanism of yeast two
hybrid system for predicting Protein-Protein interaction.
14
Q.3 Explain the Homology modeling with its step in details and Give a detail
account on different programmers for the homology modeling.
14
Q.4 Explain the 3D structure prediction and explain fold recognition and
threading method in details.
14
Q.5 Answer any two of the following 14
Write a note on combinatorial chemistry.
What is structural bioinformatics? Explain the RCSB PDB and mmCIF
file format in details.
Explain in detail the different phases of clinical trials.
Q.6 Write short notes on (any 14
CATH and SCOP
Drug Bank
Protein-carbohydrate interaction