P.G. DIPLOMA IN STRUCTURAL
PHARMACOGENOMICS EXAMINATION,
DECEMBER 2017
First Semester
Bioinformatics
LAB I COMPUTER AIDED DRUG DESIGNING
(THEORY)
(CBCS 2013 onwards)
Time 3 Hours Maximum 75 Marks
Part A (10 x 2 20)
Answer all questions.
All questions carry equal marks.
1. What is sequence alignment?
2. What is NAR?
3. What s protein structure prediction?
4. What is active site?
5. What is loop modelling?
6. Name any four protein-ligand docking software.
7. What is GROMACS?
8. What is a drug target?
Sub. Code
510105
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9. What is rational drug discovery?
10. Name any four visualization tools.
Part B x 5 25)
Answer all questions.
All questions carry equal marks.
11. What is alignment? Describe about local and global
alignment.
Or
Give the applications of biological databases.
12. What is fold recognition? Discuss briefly and also
name some tools used for fold recognition.
Or
Discuss briefly about CASP.
13. Describe about HTS.
Or
Explain SAR by NMR.
14. What are the applications and limitations of
molecular dynamic simulation?
Or
Explain about the two major types of drug design.
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15. What are the applications of computer-aided drug
design?
Or
Expand and explain briefly about ADMET.
Part C x 10 30)
Answer any three of the following.
16. Explain in detail about the algorithm used for global
alignment.
17. Discuss in detail about the steps in Homology modelling.
18. Give the detailed overview of QSAR.
19. Explain in detail about the overview of De novo drug
design.
20. Describe in detail about structure analysis and
visualization tools.