P.G. DIPLOMA IN STRUCTURAL
PHARMACOGENOMICS EXAMINATION,
DECEMBER 2017
First Semester
Bio informatics
MOLECULAR MODELING AND DRUG DESIGNING
(CBCS 2013 onwards)
Time 3 Hours Maximum 75 Marks
Part A (10 x 2 20)
Answer all questions.
All questions carry equal marks.
1. What is improper torsion?
2. Comment on PyMol.
3. Write precised account on Pi value.
4. Define the drugability of a molecule.
5. Write the Hammett Substitutent constant.
6. What is AMI?
7. Comment on the incremental construction.
8. What is Craig Plot?
Sub. Code
510104
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9. Define PES.
10. What is molecular graphics?
Part B x 5 25)
Answer all questions.
All questions carry equal marks.
11. Write brief account on the steps involved in
modeling a protein.
Or
What is Ramachandran plot? How is it useful in
validation?
12. Give a brief account on different tools and software
to identify binding site.
Or
Briefly discuss the structure based drug design.
13. Write short notes on Chemoinformatics virtual
screening.
Or
Give a brief account on Schrodinger equation.
14. What are parameters used in calculating the score
of the docked complex? Add a note on them.
Or
Write short notes on ADMETox.
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15. Give a brief account on methodology of QSPR.
Or
Briefly discuss the different aspects of molecular
mechanics.
Part C x 10 30)
Answer any three questions.
16. Explain the therapeutic target modeling and validation
techniques.
17. Write an essay on methods and applications of molecular
dynamics.
18. Discuss the strategies in drug designing.
19. Give a detailed account on QSAR.
20. Discuss the importance of cheminformatics in the
discovery of drugs.
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