Exam Details

Subject molecular modelling and pharmacoinformatics
Paper
Exam / Course m.sc bioinformatics
Department
Organization alagappa university
Position
Exam Date April, 2017
City, State tamil nadu, karaikudi


Question Paper

M.Sc. DEGREE EXAMINATION, APRIL 2017
Second Semester
Bioinformatics
MOLECULAR MODELLING AND
PHARMACOINFORMATICS
(CBCS 2016 onwards)
Time 3 Hours Maximum 75 Marks
Part A (10 x 2 20)
Answer all questions.
1. Define Energy surface.
2. Define One-electron atoms.
3. Write the Bond stretching.
4. Write the Structural Databases.
5. Define Force field.
6. Explain CASP.
7. Explain HTVS.
8. What is Poling?
9. Define Matrices.
10. Explain the Ramachandran plot.
Sub. Code
502203
RW-189
2
Sp4
Part B 5 25)
Answer all questions.
11. Describe the polyelectronic atom and molecules.
Or
Explain the new targeted drugs to treat various
diseases.
12. Give an account of the hydrogen bonding in
molecular mechanics.
Or
Explain the Quantum mechanics.
13. Give an account of Electrostatic interactions.
Or
Define general structure protein homology
modelling.
14. Describe the protein folding and unfolding.
Or
Define drug receptors interactions.
15. Briefly describe the 3D Database searching.
Or
What are the semi-empirical methods?
RW-189
3
Sp4
Part C 10 30)
Answer any three questions.
16. Give details the solving protein structures using
restricted molecular dynamic and simulated annealing.
17. Describe the some basic principles of protein structure.
18. Describe the molecular docking and its applications.
19. Give an account of chemistry of drug metabolism, drug
deactivation and elimination.
20. Explain the first principles methods for predicting protein
structure.



Other Question Papers

Subjects

  • biomolecules
  • computational approach to taxonomy and phylogeny
  • computational biology
  • elective i –– general chemistry
  • elective ii — immunology and immunotechnology
  • genomics and pharmacogenomics
  • introduction to bioinformatics
  • lab ii : biochemical and molecular biology methods
  • lab iii – mysql and perl programming
  • mathematics and biostatistics
  • molecular cell biology and genetics
  • molecular modelling and pharmacoinformatics
  • nanotechnology and advanced drug delivery system
  • principles of gene manipulation
  • structural biology