M.Sc. DEGREE EXAMINATION, NOVEMBER 2017.
First Semester
Biotechnology
Core 4 MOLECULAR BIOLOGY AND GENETICS
(CBCS 2016 onwards)
Time 3 Hours Maximum 75 Marks
Part A (10 x 2 20)
Answer all questions.
All questions carry equal marks.
1. Define replication fork.
2. Explain topoisomerase.
3. What is lytic cycle?
4. Define operon.
5. What is photoreactivation?
6. Comments on genetic mapping.
7. What is mobilizable plasmids?
8. What are transposable elements?
9. What is Karyotype.
10. What is chromosome duplication?
Sub. Code
501104
RW-833
2
Sp4
Part B x 5 25)
Answer all questions choosing either or
11. Briefly sketch on post transcriptional modification
of eukaryotic mRNA.
Or
Write short note on rolling circle model of
replication.
12. Give a short note on gene silencing.
Or
Explain about Prophage excision.
13. Discuss any three types of mutations.
Or
Explain the recombinational repairing mechanism.
14. Describe the transposons mechanism in yeast.
Or
Comments on conjugation machinery.
15. Explain about epigenetics.
Or
Discuss about the genetic disorder.
RW-833
3
Sp4
Part C x 10 30)
Answer any three questions.
Draw diagram and flow chart wherever necessary.
16. Give a detail comments on genetic codes.
17. Discuss the genome organization and regulation in
prokaryotes.
18. Write about genome damages and their repair
mechanisms
19. Explain the horizontal gene transfer mechanisms.
20. Demonstrate the structural and numerical alterations of
chromosomes.