M.Sc. DEGREE EXAMINATION, NOVEMBER 2017
First Semester
Bioinformatics
MOLECULAR CELL BIOLOGY AND GENETICS
(CBCS 2016 onwards)
Time 3 Hours Maximum 75 Marks
Part A (10 x 2 20)
Answer all questions.
All questions carry equal marks.
1. Define a cell signaling.
2. Define the term gene silencing.
3. What is cytoskeleton?
4. Define recombination.
5. What is genomic imprinting?
6. Write the regulatory elements.
7. Define the term linkage.
8. What is a gap junction?
9. What is a phenotype?
10. Salient features of pedigree.
Sub. Code
502104
RW-846
2
sp3
Part B x 5 25)
Answer all questions.
11. Explain in detail the steps involved in Mitosis.
Or
Explain with suitable illustration the structure of
lipid bilayer model of cell membrane.
12. Explain sex linked inheritance with a suitable
example.
Or
Explain in detail karyotyping.
13. Explain in detail the large scale gene expression
analysis.
Or
Explain with illustration the post translational
modification of proteins.
14. Explain the structure of a nucleus.
Or
Elaborate in detail independent assortment.
15. Explain the process of tetrad analysis.
Or
Explain in detail genetic recombination.
RW-846
3
sp3
Part C x 10 30)
Answer any three questions.
16. Explain in detail the structure and function of
mitochondria, Add a note on its inheritance.
17. Explain in detail the different mechanisms of genome
alterations.
18. Explain in detail of genome mapping techniques.
19. Explain in detail the process of extrachromosomal in
heritance.
20. Explain with neat illustrations the Mendelian principles
of inheritance.
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