M.Sc. DEGREE EXAMINATION, NOVEMBER 2017
Third Semester
Chemistry
Elective — PHARMACEUTICAL CHEMISTRY
(CBCS 2014 onwards)
Time 3 Hours Maximum 75 Marks
Part A (10 x 2 20)
Answer all questions.
1. Differentiate pro drugs from soft drugs.
2. Define the term pharmacophore.
3. Define antibiotics.
4. Give the structure of erythromycin.
5. How are anti-neoplastic agents classified?
6. Define neoplasm.
7. Give the therapeutic action of clonidine.
8. What are the different types of hypertension?
9. What is meant by chemical shift?
10. Write the general principle of chromatography.
Sub. Code
4MCH3E3
AFF-4891
2
sp4
Part B x 5 25)
Answer all questions choosing either or
11. What is the significance of lead compounds and the
site of action of drug in the process of drug design?
Or
What are prodrugs? Classify them with suitable
examples.
12. Explain the synthesis of Penicillin G.
Or
Describe the structural feature and SAR of
Chloroamphenicol.
13. Explain the synthetic route of ifosfamide.
Or
What are antitubercular drugs? How are they
classified? Give the structure of chloroquine.
14. Give the therapeutic action and synthesis of
captropil.
Or
Explain the synthetic route of methyldopa.
15. Discuss the principle and applications of UV
spectroscopy.
Or
Explain the general procedure adopted in thin layer
chromatography.
AFF-4891
3
sp4
Part C x 10 30)
Answer any three questions.
16. Write an essay on structure-activity relationship.
Explain the different pharmacokinetic phases of a
drug design.
17. Describe the structural feature and SAR of streptomycin
and terramycin.
18. Write the synthetic route of decarbazine and mefloquine.
19. Discuss the synthesis, therapeutic action and SAR of
Hydralazine.
20. Describe the principle, Instrumentation and applications
of IR spectroscopy.
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