M.Sc. DEGREE EXAMINATION, NOVEMBER 2017
Third Semester
Biochemistry
Elective — DRUG MODELLING AND DESIGNING
(CBCS 2014 onwards)
Time 3 Hours Maximum 75 Marks
Part A (10 x 2 20)
Answer all questions.
1. Define drug deign with examples.
2. What is called the pharmacokinetics?
3. What is called patent?
4. Name the new drug development process.
5. Define drug efficacy.
6. Define drug interaction.
7. Define drug absorption.
8. Define active transport.
9. Define drug database.
10. What are ligands? Give examples.
Sub. Code
4MBC3E2
AFF-4943
2
Ws8
Part B 5 25)
Answer all questions, choosing either or
11. Mention the concepts of drug development.
Or
How do you investigate the new drugs using drug
modeling?
12. Write short notes on Fast tracts approval of drugs.
Or
Brief about the target validation technology.
13. List out the margin of safety of drugs.
Or
Write notes on dose optimization.
14. Elaborate the effect of food on drug absorption in
GIT.
Or
Sketch the structure of membrane.
15. Write short notes on binding screening strategies of
ligands.
Or
Describe the uses of computer graphics in
pharmacology.
AFF-4943
3
Ws8
Part C x 10 30)
Answer any three of the following questions.
16. How did biopharmaceutics considered in drug product
design?
17. Brief about the ethics of clinical testing.
18. Illustrate the pharmacokinetic and pharmacodynamic
modeling of drugs.
19. Elaborate the transport of drugs across biological
membranes.
20. Elaborate the screening of drug databases.