M.Sc. DEGREE EXAMINATION, NOVEMBER 2017
Third Semester
Biochemistry
Elective — BIOPHARMACEUTICALS
(CBCS 2014 onwards)
Time 3 Hours Maximum 75 Marks
Part A (10 x 2 20)
Answer all questions.
1. Define prodrug. Give examples.
2. Mention any two naturally derived plant drugs.
3. What is meant by phase-I metabolism?
4. Cytochrome P-450 Comment.
5. What is LD50?
6. Define pharmacodynamics.
7. Write the structure of Tetracyclin.
8. What are secondary metabolites? Give examples.
9. What are interferons? Mention its types.
10. What are muteins?
Sub. Code
4MBC3E1
AFF-4942
2
Ws5
Part B x 5 25)
Answer all questions.
11. Write a note on the procedure followed in drug
design.
Or
Explain the objectives and role of clinical trials.
12. Describe the factors which influence drug
absorption.
Or
Exemplify the role of cytochrome P450 in drug
metabolism.
13. Give a note on drug receptor interactions.
Or
How drugs acts by the mode of enzyme inhibition?
Illustrate.
14. Discuss the chemistry and antibiotic action of
streptomycin.
Or
Explain the shikimate pathway for secondary
metabolite production.
15. What are interleukins? Write its functions.
Or
Explain gene delivery systems.
AFF-4942
3
Ws5
Part C x 10 30)
Answer any three questions.
16. Describe
Computer aided drug design
Receptor as drug targets.
17. Give an account on routes of drug administration.
18. Elaborate on
Sulphonamides
MIC and MEC.
19. Illustrate the source, structure and functions of penicillin.
20. Discuss the applications of monoclonal antibodies with its
limitations.
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