M.Sc. (Semester IV) (CBCS) Examination Mar/Apr-2018
Genetics
CANCER GENETICS STEM CELL RESEARCH
Time: 2½ Hours
Max. Marks: 70
Instructions: Section-I is compulsory. From Section-II attempt any four. All questions carry equal marks. Draw neat and labeled diagrams wherever necessary.
Section I
Q.1

Rewrite the sentence after choosing the correct answer from the given.
07
Cancer is often the result of activation of to and the inactivation of genes.
oncogenes, tumor-suppressor genes, proto-oncogenes
proto-oncogenes, oncogenes, tumor-suppressor genes
oncogenes, proto-oncogenes, tumor-suppressor gene
proto-suppressor genes, suppressors, oncogenes
About 50% of all human cancers may involve an abnormal or missing
Oncogene
Proto-oncogene
p53 gene
BRCA-1 gene
Which of the following is not a characteristic of cancer cells?
Loss of cell cycle control
Transplantability
Loss of contact inhibition
All are characteristic
Which cellular organelles are involved in the initiation of the intrinsic pathway of apoptosis?
Endoplasmic reticulum
Lysosomes
Mitochondria
Peroxisomes
Organ culture can be performed using
Raft method
Plasma clot method
Grid method
All of these
The first successfully cloned animal was
Rabbit
Sheep
Rat
Dog
The method in which the nucleus of a donor cell is relocated to an enucleated target cell is known as
Cell transformation
Nuclear transplantation
Organ transplant
All of these

Define the term:
07
Tumor suppressor
Proto-oncogene
Apoptosis
Hematopoietic Stem Cells
Organ culture
Chemotherapy
Metastasis
Page 2 of 2
SLR-UK-404
Section II
Attempt any four of the following:
Q.2
Explain in detail processes of Angiogenesis with suitable diagram.
14
Q.3
Describe mechanical and chemical disaggregation methods of animal tissue.
14
Q.4
Explain in detail role of tumor suppressor protein and add a note on P53 structure.
14
Q.5
Answer any TWO of the following:
14

Write short note on Cancer Vs Normal cell.

Write short note on Hematopoietic stem cell.

Add a note Regeneration of Bone and Cartilage.
Q.6
Answer any TWO of the following:
14

Explain role of Epigenetic in cancer.

Add a note on extra cellular matrix of tissue.

Add a note on Stem Cells in Eye Diseases and Disorders.