M.Sc. (Semester IV) (CBCS) Examination Nov/Dec-2018
Genetics
MOLECULAR MEDICINE
Time: 2½ Hours Max. Marks: 70
Instructions: Part-I, question 1 is compulsory.
Attempt any four questions from Part II
All questions carry equal marks.
Draw neat and labeled diagrams wherever necessary.
PART I
Q.1 Rewrite the sentence after choosing correct answer from the given
alternatives:
07
The β-globin gene of haemoglobin is located on chromosome
number
11 12
16 18
is the study of inherited genetic differences in drug
metabolic pathway which can affect individual responses to drugs.
Pharmacology Genetics
Pharmacogenetics Pharmacy
gene is mutated in cystic fibrosis.
CFTR actin
cadherin fibrin
Nerve tangles in alzheimer's disease is caused due to protein.
ameloid beta Tau protein
sigma delta
In DNA fingerprinting repeated sequences of DNA is used.
Variable number of tandem repeats
Verified number of tandem repeat
Versatile number of transverse repeat
Variable number of transverse repeat
Stem cell exhibits properties.
Only potency Potency and self renewable
Potency and non renewable Only self-renewable
MHC Antigen in mouse is known as
HLA H-2
ASB HSB
Q.1 Define the following terms. 07
Amelyoid plaques
DNA fingerprinting
Microarray
Pharmacogenetics
Stem cells
Gene therapy
Amniocentesis
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SLR-VK-326
PART II
Answer any four of the following:
Q.2 Write a brief account on Stem cells and its properties. 14
Q.3 Explain in detail diseases related to hemoglobin gene mutation. 14
Q.4 Explain in detail steps involved in drug discovery and its design. 14
Q.5 Answer any TWO of the following:
Give an account on phenyketonuria.
Explain Totipotant stem cell.
Give a brief account on blood and blood group antigens.
14
Q.6 Write short notes on any two 14
Give an account on human genome project.
Explain non viral methods of gene transfer.
Give an account on DNA fingerprinting and its applications.