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Hall Ticket Humben .
Department of Animal Sciences
ENTRANCE EXAMINATION, February 2014
Ph. D Animal Sciences
Time: 2 hours Maximum Marks: 75
INSTRUCTIONS: PLEASE RIMlBEFORE ANSWERING
Enteryour hall ticket number on this sheet and the answer sheet
Answers have to be marked on the OMR answer sheet following the instructions
provided there upon.
Handoverthe OMR answersheetatthe end ofthe examination totheInvigilator.

All questions carry one mark each. Answer all, or as many as you can.
0.33 mark win be deducted for every wrong answer.
There are a total of 14 pages in this question paper. Answer sheet will be

provided separately. Check this beforeyou start answering.
The question paper consists ofpart A andpart B. The marks obtained in Part A will be
taken in consideration in case of a tie Le., when more than one student gets eqUIII
marks, to prepare the merit list.


PART "A"
1. Which one of the following is NOT an anabolic product of nitrogen assimilation?
Glutamate B) Urea
Aspartate D) Glutamine
2. Chemical reaction that can be best predicted for the direction is
B)
C)iG P) AE
r l t.....
z
3. Identify the odd one
Syncytiotrophoblasts and human chorionic gonadotropin
Granulosa cells and estradiol
4. Lactational amenorrhea is
Polycystic ovarian syndrome
Causal factor for mastitis

5. Pyrosequencing is especially useful for
Sequencing repetitive DNA regions in multiple individuals
Sequencing short DNA regions in multiple individuals
6. Choose the mismatch
Cri-du-chat syndrome -5p
Retinoblastoma 14

7. CD40 ligand is seen only on
Macrophages
Helper T cells

8. Neutrophil chemotaxis is mediated by
IL-8
Interferon

Sertoli cells and dihydrotestosterone
Chromaffin cells and adrenaline
Temporary postnatal infertility
Induced lactation
Sequencing highly condensed DNA regions
Sequencing DNA regions with high AT content
Patau Syndrome 13
Edwards syndrome 21
. Cytotoxic T cells Dendritic cells
E-selectin
IgM

9. Which one of .the following pairs of molecules could NOT be able to form the hydrogen bond with each other?

.ilo

».3ttc f


r1






. l

.•..



d-to

10. Detection of odors (the sense of smell) is mediated by
Ungated Na+ channels Gated cation channels
Gated anionic channels G-protein coupled receptors

11.
What is the effect of increased palmitoleate levels on the viscosity of the E. coli outer membrane at a constant temperature?

Decreased viscosity Increased viscosity
Viscosity remains unaltered Initially decreases and then increases


12.
Attachment of multiple copies of a smail, highly conserved protein called----to a substrate protein targets the substrate protein for degradation. ·

Cyelin Tubulin
Ubiquitin Actin


13.
Male breast cancer is primarily associated with mutations in


BRCAI BRCA2
NFl RET


14. The common intermediate 01 carbohydrate, protein and lipid metabolism is
Ammonia
Acetyl coA

15. In relation to natural selection, evolution is Process

Outcome

Pyruvic acid phosphoglyceraldehyde
Mechanism Purpose
16. Which ofthe following viruses CANNOT translate their genome immediately after
entering the cell?
+ve sense RNA viruses
Both

17. What are the components ofceramide?
Sphingosine -fatty acids Sphingosine fatty acids phosphoric acid
18. At physiological pH, a protein rich in buffering capacity.
Lysine
Aspartic acid

-ve sense Rl'iA viruses
Phages
Sphingosine phosphoric acid
Sphingosine Glycerol
acid provides maximum
Histidine Leucine
19. How many moles of Ca(N03h are there in 75 ml ofO.25M solution? 0.00333 mol
0.0188 mol
3.33 mol 18.8 mol 20. What is the of a solution with a pH of 9.0?
1X 10-5M 1X 10-9M
1X 10-6M 1X 10-4M

21.
Choose the nucleoside analogue used as anticancer drug?

Methotrexate 6-mercaptopurine
Vinblastine Cytosine arabinoside


22.
Difference between paracentric and pericentric inversion is


The placement of centromere in the The involvement of centromeres In
inversion the inversion

The number of genes involved in the The position of the inversion on the
inversion chromosome

23.
Pox virus replicates in

Cytoplasm Nucleus
Both Intercellular space


24.
Two-month old breast-fed baby contains maternal circulation

IgA IgM
IgG IgE


25.
Widows peak hairline in humans is dominant to non-widows peak hairline. If a person has a widows peak hairline, what is his or her genotype?


Must be homozygous dominant Must be homozygous recessive
Must be heterozygous Either heterozygous or homozygous
dominant

I t

PART "B"

26. If an X-linked recessive disorder is in Hardy-Weinberg equilibrium and the, incidence in males equals 1 in 100, then the expected incidence of homozygous females would be
1in 1000 1in4000
1 in 10000 1 in 40000

27. Ig idiotypes are found in the
Constant region ofthe heavy chain Constant region ofthe light chain
Hinge region Variable region of both heavy and light chains
28. Which of the following is a major neuron specific phosphoprotein?
Synapsin I calmodulin
GAP-43 Calpain

29. Which of the following co-transporter is a symporter?
Glucose-Na+ co-transporter of Na+ co-transporter of fibroblast
intestinal microvilli plasma membrane

H+ -sucrose co-transporter of plant Na+ -Ca2 co-transporter: found In
vacuoles cardiac muscles

30.
The presence of anti-insulin receptor antibodies in humans causes

Type A insulin resistance Type B insulin resistance
Type 1 diabetes Type 2 diabetes


31.
Which of the following is caused by trinucleotide (triplet) expansion?


Cystic fibrosis . Duchenne muscular dystrophy
Huntington disease Osteogenesis imperfecta

32. The alpha-helical structure of globular proteins is best determined by which of the following technique?
UV absorption spectroscopy Electron spectroscopy
Fluorescence spectroscopy Circular dichroism

33. Thick filamental skeletal muscles are composed of
35.
Secretory IgA protects external mucosal surface by

36.
Which one ofthe following hormones is considered non..fuoctional?

Somatostatin Somatomammotropin

37.
Why is the Tm of DNA monitored using the absorption of UV light at 260 om?


Triggering mast cells Recruiting phagocytic cells
Preventing microbial adherence to Binding to the epithelial cells
the mucosa

GC base pairs absorb more IN than AT Base pairs absorb more UV than AT base pairs GC base pairs
'Single stranded DNA absorbs more Double stranded DNA absorbs more IN than double stranded DNA IN than single stranded DNA
38. Which one of the cellular organelles has got major role in reproduction and development?
Goigi complex Lysosomes
Peroxisomes Mitochondria

39. The sequence element on the DNA template which is first recognized by RNA polymerase II in Gakaryotes is known as the
UTR Enhancer
TATA box TATAAT Box

40. Gels of plasmid DNA preparations show a major'band of
LinearDNA Supercoiled DNA
Coiled DNA Chromosomal DNA

41. Propagation of a regenerative action potential along an axon can be accelerated by which one of the following?
By increasing the transmembrane By decreasing the axoplasmic
resistance resistance

By narrowing the axon diameter Shortened intennodallengths
42. Which of the following statement is NOT correct?
Both a and tubulin bind GTP tubulin hydrolyzes the bound GTP toGDP
a tubulin hydrolyzes the bound GTP G·TP bound to a tubulin is never toGDP hydrolyzed. or exchanged with free nucleotides
43. The folding of sheet of cells, the migration of cells and cell death all are mechanisms of Pattern formation Morphogenesis Differentiation .D) . Growth
44. Adult human bone grows
Only at the extreme ends of Only in the center -diaphysis
epiphysis

Throughout its length Only. at growth plates between epiphysis and diaphysis
45. What do plasma membrane extension and acrosome reaction have in common?
Both involve movement driven by Both involve release of hydrolytic actin polymerization enzyme
Discharge of calcium ions from the Acting sequestering protein thymosin
cell binds to G actin and blocks
polymerization

46.
Inclusion bodies known as 'Negri bodies' are found in the infections of

Hepatitis C virus .. Foot and Mouth disease virus
HIV virus Rabies Virus


47.
Which'of the following amino acids is NOT converted to Acetyl coA upon metabolism?

Valine Tyrosine
Tryptophan Lysine


48.
A culture started with 4 cells and ended with 256 cells. How many generations did the cell go through?

A)5 B)3
C)6 D)8


49.
The glycoprotein containing mucoid substance that separates the granulosa cells,; from the oocyte in an ovary is


Zona pellucida Ectodermin
Chorodin binding protein ·D) Ubiquitin

TTII"II'
n
50. The following holds single microRNA
Involved in translational arrest Involved In translational arrest
degradation ofonly one mRNA degradation ofmultiple mRNAs

Involved In only degradation of Involved ill degradation of ribosomal
multiple mRNAs RNAs

51.
The maximum possible volume of air which can be during inspiration is called as

Tidal air volume Vital lung capacity
Complementary air volume Total lung capacity


52.
Miracidium is a larval stage in the development of


Taenia solium Fasiola hepatica
Ascaris Echinococcus

53.
Which of the following is a non-specific (systemic) autoimmune disease?

Hashinomoto's thyroiditis Pernicious anaemia
Systemic lupus erythematosus Myasthenia gravis


54.
The condition in which one hormone is elevated to pathologically high levels and mimics the action of another hormone by binding to its receptor is referred to as

Hormone-receptor internalization Induced hormone-receptor activity
Specificity spillover action Hormone receptor cross aggregation


55.
Urocortin is secreted by


Urinary bladder Kidney
Brain Liver

56. A C.9-steroid formed by the addition ofanother methyl group to C.o is Agonane
A pregnane
An esterase

An androstane
57. The undue tendency for closely linked genes on a chromosome to remain associated rather than undergo genetic randomization is termerd as
60. Changes in ion permeability of membrane of a neuron alter the membrane potential of the cells. Which of the following would cause hyperpolarization?
Increase in permeability Decrease in CI-permeability
Increase in Na+ permeability
Decrease in permeability
61. Platyhelminths are described as
Flatwonns, triploblastic, Flatworms, diploblastic, acoelomates
acoelomates

Flatworms, diploblastic coelomates Flatworms, triploblastic, coelomates

62. Neoteny in axolotl larva is the phenomenon where it
Gains new tone ofbody muscles
Becomes sexually mature amdcan reproduce but retains systems in their larval state
Metamorphoses in normal manner
Prematurely retinas all the larval
systems without any exception

63. Which of the following relatives of an individual most likely to share a common HLA haplotype?
Father Mother
Sister Son

64. Enhancer sequences are characterized by the following means
DNAseI hypersensitivity, H3K4me2 and p300 binding
DNAseI h)1'ersensitivity, H3K9me2 and p300 binding
65. The term "Chromothripsis" refers to
Break of chromosomes during apoptosis
Breakdown of chromosomes during stress
DNAseI insensitivity, H3K4me2 and p300 binding
DNAseI insensitivity, H3K9me2 and p300 binding
Breakdown of chromosomes during cancer
Break of chromosomes during recombination
66. A culture medium on which only gra;m positive organisms grow and a yellow halo surrounds Staphylococcus aureus colonies is called
Selective medium Differential medium
Both Enrichment medium

67. Platelet counts go down in the infections of
Chikungunya virus Ghicken pox virus
Dengue virus Small pox virus .

68.
Which of the following forces is most favorable for protein folding

Vander waals interactions Hydrophobic interactions Hydrogen bonds Conf0fi!lational entropy

69.
Which of the following microtubule is less stable and exhibit little cycling between disassembled and assembled states?


Axonal microtubule microtubule
Spindle microtubule Axonal, flagellar microtubules have same stability and spindle
70. DNA methylation is associated with

GT-AG CpG islands CAATbox TATABox
71.
Pulse-field gel electrophoresis is useful for separating

Single stranded RNA DNA fragments in identical length Large DNA fragments Chromosomal DNA

72.
Initial milk ejection from breast is accomplished by

Somatomammotropin Oxytocin Placental lactogen Prolactin

73.
Which one of the following is odd one with reference to oxygen?


Myoglobin Hemoglobin Hemocyanin Globulin
74. What will be the molarity of a solution having 72.06g of BaCh in required amount of water to make up 800 ml?(Mol mass ·of BaCh is 208.23 g1mol)
0.433 M
4.33 M 5.33 M
O.866M
75. The grey crescent of frog's embryo represents the future
Anterior side ofdeveloping embryo Posterior side ofdeveloping embryo
Ventral embryo side of the developing Dorsal side ofthe developing embryo


For rough work