B.Pharmacy (Semester VI) (CGPA) Examination, 2018
pharmacology II
Day and Date Wednesday, 16-5-2018 Max. Marks 70
Time 10.30 a.m. to 1.30 p.m.
Instructions Mention appropriate question numbers and sub-question numbers.
Figures to right indicate full marks.
Use of appropriate and exemplary algorithms, flow charts or illustrations should be assessed similar to descriptive answers.
I. Choose an appropriate alternative for following multiple choice questions (1×15=15)
Identify a diuretic showing highest degree of Hypokalemia among the following
Furosemide Hydrochlorothiazide
Acetazolamide Indapamide
Doubling of plasma concentrations of Digoxin may occur upon concurrent use of Quinidine because
Reduced tissue binding of Digoxin
Reduced Renal and Biliary Clearance of Digoxin
Reduced Digoxin Metabolism
Both and
A newer beta blocker which has become popular as an antihypertensive is
Celiprolol Atenolol Acebutalol Nebivolol
Drug peak related adverse effects of Nifedipine can be reduced by following precautions EXCEPT
Smaller starting doses
Use of daily doses in divided fractions
Use of retard formulations
By using it every alternate day
The drugs included in class of anti-arrhythmics have the highest propensity to induce an arrhythmia themselves.
Class IA Class IB Class IC Class II
P.T.O.
Seat
No.
Set
P
Set P
SLR-TA 42 *SLRTA42*
is rare but the most serious adverse effect of statins.
Rise in serum transaminases Myopathy
Bowel upset Sleep disturbances
is the safest anticoagulant in pregnancy.
Warfarin Phenindione Heparin Dicumarol
A thrombolytic capable of causing hypersensitivity reactions is
Urokinase Streptokinase Alteplase Reteplase
Longer acting beta adrenergic agonists used as bronchodilators include
Phenylephrine Salbutamol Salmetrol Terbutalin
10) A mast cell stabilizer useful as a prophylactic in bronchial asthma is
Montelukast Ketotifen Budesonide Tiotropium
11) Cramping abdominal pain is an adverse effect observed with
Castor Oil and Senna Ispapagula and Bran
Racecadotril Liquid Paraffin
12) Anti-androgenic effects are seen with
Cimetidine Ranitidine Roxatidine Famotidine
13) Omeprazole is activated at pH of before it binds with the proton pumps.
7
14) Specific antidote for OPC poisoning is if treatment is started early; however is routine use antidote for the OPC poisoning.
Fomepizole; Ethanol Pralidoxime; Atropine
Doxapram; Naloxone Amphetamine; Flumazenil
15) Emesis should not be tried in case of poisoning with
Belladona Corrosive substance
Morphine OPC
II. Answer any five of the following
'Diuretics are classified according to their potency'. Explain.
List out different classes of antiemetics with specific examples.
Outline the treatment of shock with special reference to use of Positive Inotropic Agents.
Set P
Write mechanism of action and adverse effects of Castor Oil and Liquid Paraffin.
Enumerate different classes of anti-arrhythmic drugs with appropriate examples.
Describe manifestations, first aid and management of OPC poisoning.
III. Answer any three of the following (3×10=30)
Write an entire pharmacological account of digital is including mechanism of action, pharmacological actions, pharmacokinetics, adverse effects, interactions, contraindications and uses.
Describe the strategies for drug use in asthma in a classified manner. Write an account on use of Bronchodilators in termination of an ongoing attack of asthma.
Write mechanism of action and adverse effects of Organic Nitrates and Quinidine.
Classify antihypertensive drugs with examples. Explain use of antihypertensive depending on staging of hypertension.