B.Pharm. (Semester VIII) (CGPA) Examination, 2018
Pharmaceutical Analysis VI
Day and Date Monday, 17-12-2018 Total Marks 70
Time 2.30 p.m. to 5.30 p.m.
1. Multiple choice questions. (15×1=15)
No of orientation for magnetic nuclei is given by formula.
2I 2 2I 1 2I 2 2I 1
The chemical shift value for carboxylic proton is Delta ppm.
10 12 4 6 9.5 10 7 9
Most intense peak in the mass spectrum is called as Peak.
Isotope Fragment
Base peak Rearrangement
Bursting strength test is carried out for packaging material.
Metallic sheet Glass
Rubber closure Aluminium foil
are the reagents used for reducing test of packaging material.
KMnO4 H2SO4
KI All of these
Number of signals for 1-propanol is
3 2 4 5
McLafferty rearrangement is seen in the m/z ion having aldehydic, ester,
carboxylic, ketone or amide functional group with suitably placed
Abstractable hydrogen.
Alpha Beta Gamma Delta
ion source is used for studying high molecular weight biomolecule
samples.
MALDI Electro spray ionization
FAB EI
Seat
No. Set P
Set P
SLR-TV 52 *SLRTV52
Which of the following is not the components of quality management system
Quality assurance Quality validation
Good manufacturing practice All of these
10) is the central value of all the observations arranged from lowest
to highest.
Mode Mean
Median Standard deviation
11) Time of flight mass analyzer, the separation of the ions takes place due to
different of ions.
Magnetic dipole Velocities
Nuclear spin Potential
12) Concurrent validation is carried out
During production During product development stage
After production All of these
13) is the lowest amount of analyte in a sample that can be detected
but not necessarily quantitated under stated experimental conditions.
Limit of detection Limit of quantitation
Range Assay
14) What is the median of the data 10, 12, 8
4 5.5 4.5 5
15) Standard Error of Mean (S.E.M.) of a sample can be calculated by
Dividing variance by sample mean
Dividing S.D. by sample mean
Dividing S.D. by square root of number of variance
Dividing mean by mode sample
2. Answer any five of the following questions.
Write a note on T-test.
Draw a neat labeled diagram of NMR spectrometer. Give its principle.
Write on magnetic deflection mass analyzer used in mass spectrometry.
Write on accuracy and precision validation parameter of analytical
method.
Set P
*SLRTV52 SLR-TV 52
Describe bursting strength and hydrolytic resistance test for packaging
material.
Draw the structure of organic sample having molecular formula C4H8O2
and is an ester with NMR signals at 4.1 δ as quartet, 2.1 δ as singlet and
1.2 δ as triplet.
3. Answer any three of the following questions. (3×10=30)
Write on principle, sample inlet system and applications of mass
spectrometry.
Write on process validation and quality assurance.
Explain with suitable examples factors affecting chemical shift.
Write on Electron Impact, Chemical ionization as an ion source in mass
spectrometry.