B.Pharm. (Sem. III) (New CBCS) Examination, 2018
PHYSICAL PHARMACEUTICS I
Day and Date Tuesday, 11-12-2018 Total Marks 75
Time 10.30 a.m. to 1.30 p.m.
I. Choose the correct alternative (20×1=20)
An Azetropic mixture of two liquids boils at lower temperature than either
of them when
It is saturated
It shows positive deviation from Raoult's law
It is Metastable
It shows negative deviation from Raoult's law
Colligative properties are the properties of the solution that depends upon
Nature of molecules Quality
Physical properties Number of Molecules
The solubility of gases increases in liquid with decreasing
Mass Volume
Temperature Pressure
If a solution has to be a buffer, its pH should be
As its pKa value At is Ka Value
At 7 At 14
The vander Waal radius of hydrogen atom in water molecule is
1.2 A° 1.4 A°
1.6 A° 1.8 A°
Normal pH of blood is
7.0 7.2
7.1 7.4
Seat P
No.
Set
SLR-TV 16 *SLRTV16*
Set P
The Heat of vaporization of water molecules at atmospheric temperature
is
1260 J/g 2260 k.cal
2260 J/g 1260 k.cal
Ions which are produced from ligands are
Cations Complex ion
Anion All of them
Terms and conditions of Nernst's law
Constant Temperature Dilute solution
Non-miscible solvents All
10) In Nematic crystals, molecules are mobile in how many dimensions.
One Two
Three Zero
11) Buffer Capacity is the maximum at
pKa pH pKa pH
pka Concentration pka pH
12) At Constant temperature the solubility of gas in a liquid is proportional to
the pressure of the gas above it is called as
Raoult's law Henry's law
Graham's law None of above
13) The Amorphous form of drug dissolves than the crystalline
form.
Faster Slower
Equal to one Does not dissolve
14) Spreading agents usually have an HLB value in the ranges
0-3 9-12
7-9 8-16
*SLRTV16* SLR-TV 16
Set P
15) The pKw at 25°C is
7.0 10
5.0 14
16) When a suitable pH of solution is added to an acidic drug, the solubility is
promoted due to
Enhanced ionization Formation of drug solvates
Formation of salt Improved stability
17) The Partition coefficient considers the solute concentration as one of the
following (molecular) species
Dimer Dissociated Ion
Hydrate and Solvate Monomer
18) Which of the following is not a multiple ligand
EDTA Ammonia
Deferoxamine Dimethylglycoxime
19) Protein binding distribution of drugs.
Increases Prevents
Decreases None of these
20) The rapid increase in solubility of a surfactant solution above a definite
temperature is known as
Cloud point Krafft point
CMC Triple point
II. Solve any two (2×10=20)
Explain in detail methods used for liquification of gases.
What is adsorption isotherm Discuss in detail Freundlich and Langmuir
adsorption Isotherm.
Define partition coefficient. Explain its derivation and principle behind
Association and dissociation of molecules.
Set P
SLR-TV 16 *SLRTV16*
III. Solve any seven
Define Critical Solution Temperature. Write note on UCT and LCT.
What is Kinetic Molecular Theory Give its assumptions for Kinetic Molecular
Theory.
Explain factors affecting on solubility of gases in liquids.
Explain buffer equations for weak acid and its salt.
Discuss methods used to determination of pH.
Discuss methods for determination of Complexation.
Explain the mechanism of Solute-Solvent Interaction.
Write note on Eutectic Mixtures and Polymorphism.
Discuss in detail Spreading Coefficient.