B.Pharm. (Semester III) (New CBCS) Examination, 2018
pharmaceutical organic chemistry II
Day and Date Saturday, 8-12-2018 Max. Marks 75
Time 10.30 a.m. to 1.30 p.m.
I. Choose the most appropriate answers from the following answers (20×1=20)
Identify a compound which is non-aromatic, from the following
Cycloheptatrienyl cation Cyclobutadiene
Cycloheptatriene Cyclohexatriene
An a mine with a value of is more basic.
11 7.8
4 0.78
Identify the following reaction
(RCO)3 Glycerol R'OH (Excess)
Trans-acidification Trans-esterification
Hydrolysis None
The correct starting material for preparing esters by Fischers method is
RCONH2 (RCO)2O
RCOOH RCOCl
Anthracene on nitration yields derivative.
1-nitro 2-nitro
9-nitro 2-dinitro
Reichert-Meissel number indicates volatile but water Small Chain
Fatty Acids.
Soluble Insoluble
Miscible None
Identify the functional group which increases acidity when present on a
phenol
-CH3 -CH3O
-OH -NO2
P.T.O.
Seat
No. Set P
Set P
SLR-TV 15 *SLRTV15*
Least basic of the following compounds is
R2NH R3N
ArNH2 R NH2
Correct name of the compound with chain
at 4-position of C6H4OH is
propyl Phenol
propyl Phenol
2-OH-3-ethyl-3- hydroxyl phenyl propane
None
10) Product obtained on heating phthalic acid in presence of ammonia is
Maleimide Phthalimide
Phthalic anhydride None
11) Which acid with pKa value is the most acidic.
10 2
8 4
12) Most common fatty acid among the natural FAs is
Caproic Myristic
Oleic Linoleic
13) The product of reaction between Cycloproane and Br2 is
Cyclopropane
1-Bromo Cyclopropane
dibromo Cyclopropane
tribromo Cyclopropane
14) Identify the correct structure for Linoleic acid.
18 0 18 1
18 2 18 3
15) 4-sulphonate derivative of phenols is formed at
100°C 0°C
25°C -15°C
Set P
*SLRTV15* SLR-TV 15
16) Oxidation of Phenanthrene with ozone yields
Diphenyl dicarboxyl
Diphenyl dicarboxaldehyde
9,10-diphenanthrone
None
17) Saponification value of oil indicates in an oil sample.
Free fatty acid
Unsaturation
Mol. wt
Average mol. weight
18) According to Bayer, angular strain in cyclobutane is
24°
0° 9°
19) Chloro benzene on nitration yields derivative.
o-nitro p-nitro
m-nitro p and m-nitro
20) Which of the reaction is not possible when replacement reaction with
diazonium salt is carried out
Hoffmann
Gomberg
Scheimann
Sand-Meyer
II. Answer any two questions of the following (2×10=20)
What is aromaticity How it could be explained using Huckel's rule. Describe
EAS reactions in benzene.
What is acid value What is the importance of its determination
List and explain chemical reactions of aromatic acids.
Discuss
Chemical reactions of Phenanthrene.
Two methods of preparation of cyclobutane and cyclopropane.
Set P
SLR-TV 15 *SLRTV15*
III. Answer any seven questions of the following
Write five chemical reactions undergone by aromatic amines.
Explain how Naphthalene is synthesized in the laboratory.
Explain how basicity of aromatic amines changes with substituents on the
ring and on the amine
Explain the chemical basis for "rancidity of oil" and methods to prevent it.
Write the structure and uses of Diphenyl methane Anthracene.
Write two methods of preparation for cyclopropane and cyclobutane.
List and describe special reactions of Phenols.
Describe the principle, method and significance of Saponification value
determination of an oil sample.
Demonstrate with two examples how diazotization can be used for attaching
a second group at a specific point on a benzene ring.