MAY 2017 Sub. Code: 4032
M.Sc. MEDICAL PHYSICS EXAMS
SECOND YEAR
PAPER II CLINICAL RADIATION BIOLOGY
Q.P. Code: 284032
Time Three hours Maximum 100 Marks
I. Elaborate on: x 20 40)
1. Discuss with a neat diagram the direct and indirect methods of Ionizing radiation
interaction with cell. Explain the formation of free radicals and its action on
human cells.
2. Explain in detail the Time Dose Fractionation model. Explain how this is used to
apply correction for gap in Radiation Treatment fractionation.
II. Write notes on: (10 x 6 60)
1. Single and double strand breaks.
2. Point mutations.
3. Discuss cell survival curve.
4. Discuss with reference to early and late reactions.
5. Cumulative Radiation Effect (CRE).
6. Discuss site specific symptoms for head and neck cancers.
7. Chromosome aberrations.
8. Explain the relationship between LET and RBE.
9. Re-oxygenation.
10. Target theory.