1. The development of embryos from the cells of nucellus is known as

Apospory

Apomixis

Apogamy

Parthonogenesis

2. During photorespiration, the reactive oxygen species, H202 is produced in

Glyoxysome

Lysosome

Dictyosome

Peroxisome

3. The scientist who received Nobel Peace Prize in 1970 in recognition of his contribution to World Peace through increasing food supply is

H. G. Khorana

N. Bourlag

M. S. Swaminathan

C. Subramaniam

4. Which of the following statements about 'Kinetin' is INCORRECT?

Tryptophan is a precursor for de novo biosynthesis of kinetin

Adenine-type cytokinins such as kinetin are synthesized in roots or actively dividing cells

Kinetin was discovered as a breakdown product of DNA

Kinetin enhances leaf senescence

5. Cinnamomum camphora, a source of camphor that is a component of incense and used as medicine, belongs to the family

Lamiaceae

Lauraceae

Malvaceae

Apocynaceae

6. What atoms are linked (N-B-glycosidic linkage) in the adenine base with the sugar?

N-9 atom of adenine ring is covalently attached with C-l of sugar

N-1 atom of adenine ring is covalently attached with C-l of sugar

C-5 in the adenine ring is covalently attached to with C-l of sugar

N-5 of adenine ring is covalently attached to with C-l of sugar

7. What activities are associated with RNA enzymes?

Nuclease activity

Polymerase activity

Nuclease and polymerase activity

Topoisomerase activity

8. How do drugs known as statins lower blood cholesterol concentrations?

Inhibit HMG CoA reductase

Inhibit acetyl CoA carboxylase

Inhibit fatty acid synthase

Inhibit cycloxygenase

9. The action potential in a nerve cell results from the movement of

Na+ions from extracellular to intracellular fluid

Na+ions from intracellular to extracellular fluid

ions from extracellular to intracellular fluid

ions from intracellular to extracellular fluid

10. The formation of a peptide bond between two amino acids is an example of a

cleavage reaction

condensation reaction

isomerisation reaction

oxidation reduction reaction

11. Which one among the following lS the correct expreSSlOn of Henderson-Hasselbalch equation?

pKa =pH log I

pH =pKa log I

pH pKa -log I

pH =pKa log I

12. A weak acid, HA having pH 4.7, dissociates exactly half of its original concentration, what will be the pKa of the weak acid?

2.3

4.7

9.4

5.7

13. Consider two univalent elements A and B. A is strongly electropositive and B is strongly electronegative. Which of the following compounds is most likely to form?





A-B

A=B

14. In B-decay, the total number of particles in the nucleus

decreases by four

decreases by two

remains the same

decreases by one

15. What should be the age of a fossil for meaningful determination of age by carbon-14 dating?

6 years

6 million years

10000 years

any age

16. Which of the following classes of phylum Arthropoda lS characterized by a lack of respiratory and circulatory systems?

Branchiopoda

Pycnogonidia

Merostoma

Arachnida

17. Where is the biological clock that controls circadian rhythms in mammals located?

suprachiasmatic nuclei of the hypothalamus

suprachiasmatic nuclei of the pineal gland

bunch of neurons in posterior pituitary gland

axonic nuclei of diencephalon

18. Antigen-presenting cells (APCs) are a heterogeneous group of immune cells that mediate the cellular immune response by processing and presenting antigens for recognition by certain lymphocytes. Which of the following is NOT a 'classical' antigen presenting cell?

T cells

Langerhans cells

B cells

dendritic cells

19. Galapagos finches are closely-related species but they differed in beak size and beak depth, exemplifying the phenomenon referred to as 'character displacement'. This phenomenon known as character displacement is associated with

sympatric species

allopatric species

peripatric species

pioneer species in a primary succession

20. What is the in M for a solution with pH 8

8

6



10^8

21. List the following carbocations in order of increasing stability

<img src='./qimages/16039-21.jpg'>

III<II

III I<II

II<I<III

I<II <III

22. Which one of the following receptor types mediates both odorant and bitter taste signals?

G-protein coupled receptors

EGFR

nuclear receptors

Receptors with tyrosine kinase activity

23. If an enzymatic reaction has a standard free energy change of kcal/mol, the equilibrium constant is

Greater than one

Less than one

Zero

Not determinable from the value of AG°

24. Increased protein use is accompanied by an increased dietary requirement for

Ascorbic acid

Cobalamin

Pyridoxine

Riboflavin

25. In biological membranes, integral proteins and lipids interact mainly by

Hydrophobic interactions

Ionic bonds

Covalent bonds

Hydrogen bonding

26. Which of the following are the end products of anaerobic respiration in humans?

CO2

Lactic acid

Ethyl alcohol

Pyruvate

27. Which of the following statements about the control of glycogen synthase regulation by insulin is/ are correct?

Glycogen synthase kinase 3 is activated in the presence of insulin

The phosphorylation by glycogen synthase kinase 3 is inhibited by insulin

Insulin activates protein kinase B that phosphorylates glycogen synthase

Glycogen synthase kinase 3 is inactivated by a protein phosphatase

28. Which of the following statements about one-carbon transfer reactions in purine and pyrimidine nucleotide synthesis are correct?

Tetrahydrofolate is used for the one-carbon transfer in purine nucleotide synthesis

N10-formyltetrahydrofolate is used as the one-carbon donor in purine nucleotide synthesis

N5-methyl tetrahydrofolate is used for the one-carbon transfer in purine nucleotide svnthesis 5 10

N-methylene tetrahydrofolate is used in the synthesis of dTMP from dUMP

29. Which of the following statements about the carbon skeletons of amino acids are correct? Please select all that apply.

Ketogenic amino acids can give rise to acetyl-CoA

Glucogenic amino acids can give rise to glucose in starvation

Ketogenic amino acids are converted to ketone bodies

Some amino acids are both glucogenic and ketogenic

30. Absorption ofUV-visible light by a compound brings about the transition from

n to cr*

n to

cr to cr*

n to

31. According to Beer-Lambert Law, on which of the following absorbance does not depend?

Colour of the solution

Solution concentration

Size of the sample

Distance that the light has travelled through the sample

32. A number which is assigned to each atom or ion in a compound which explains its degree of oxidation is called

oxidation degree

oxidation number

oxidation state

redox degree

33. Which of the following statements about genes are CORRECT?

A gene can exist as more than one allele.

Organisms inherit two alleles for each trait.

Allele pairs separate with a single allele for each trait during gamete formation.

Meiotic recombination brings both alleles to the same chromosome

34. Which of the following statements are CORRECT?

In test cross, the FI hybrid is crossed only to recessive parent

In a back cross, the FI hybrid is crossed to either of the two parents

One can determine the homozygosity or heterozygosity of the parent by a test cross

Both types of crosses are performed to confirm independent segregation

35. Which of the following compound(s) have both covalent and ionic bonds?

KCN

AlCl3

H2S04

CH3Cl

36. Rate constant of a chemical reaction depends on the

initial concentration of reactant

concentration of product

temperature

time of reaction

37. Which of the following decreases vapour pressure of water kept in a sealed vessel?

Decreasing quantity of water

adding salt to water

decreasing volume of vessel by half

decreasing temperature of water

38. The change in Gibbs energy and entropy can be used to predict the thermodynamic nature of a reaction. Which of the following statement(s) are correct?

when AG is zero, the reaction is in equilibrium

spontaneous reactions have a AG in the negative

spontaneous reactions have a AG in the positive range

temperature of the reaction does not influence AG

39. Choose all the correct statements:

Microspore is a haploid cell that will develop into a male gametophyte

Megasporocyte is a diploid cell that will give rise to female gametes

Integument develops into seed coat

Calyx and corolla collectively refer to petals and sepals respectively

40. Chordata is a large and diverse group of animals. Which of the following characteristics distinguish chordates from other animals?

mammary glands

a dorsal hollow nerve cord

external ears called Pinnae

a post anal tail

41. In an autoimmune disease, antibodies and immune cells target body's own healthy tissues. Which of the following disorders diseases can develop when immune system destroys body's own cells?

type 1 diabetes

Hashimoto's thyroiditis

erythroblastosis fetalis

systemic lupus erythematosus

42. Given below are some statements related to antigens. Select all the statements that are correct.

An epitope is a region of an antigen against which only one kind of antibody is produced.

The difference between the immune response of two individuals to the same antigenic epitope may be because of their MHC molecules.

The T cell epitopes should be on surface so that they can be easily available to T-cell receptors.

B-cell epitopes lose their immunogenicity when a protein antigen is denatured by heat.

43. A group of scientists measures the circumference of acorns in a population of oak trees. After calculations, they observed that the most common circumference is 2 cm. Considering that stabilizing selection is operating on this population, which of the following statement(s) will be correct?

Even after 10 generations, the most common circumference of the acorns in the population will be around 2 cm.

The oak trees with acorn sizes much greater than 2 and much lesser than 2 will contribute high number of offsprings to the next generations

The oak trees with acorn sizes much greater than 2 and much lesser than 2 will contribute fewer offsprings to the next generations

The oak trees with acorn sizes much lesser than 2 will contribute maximum offsprings to the next generations

44. Two species of ants live in a stratified distribution in the soil of farmland. It was observed that ants of species A were concentrated in the lower stratum of the soil that was more moist than the upper stratum, while the ant of species B concentrated in the upper drier soil stratum. When you removed species B from the upper stratum, you observed that species A did not attempt to occupy the empty upper stratum. However, when you removed species A from lower stratum, species B occupied the lower soil stratum as well. With these observations, which of the following inferences may be considered correct?

The realized niche of species A was the same as its fundamental niche.

The realized niche of species B was much smaller than its fundamental niche.

The realized niche of species A was much smaller than its fundamental niche.

Species A was a more successful competitor in the lower moister soil stratum.

45. Which of the following animals is a brood parasite?

Anolis lizards

Fruit flies

cuckoo catfish (Synodontis multipunctatus)

cyprinid minnow (Pungtungia herzi)

46. Which of the following are non-parametric tests:

Student's t-test

Spearman's rank correlation test

Wilcoxon rank sum test

Kruskal-Wallis test

47. In order to compare means and variances with statistically significant differences between more than two groups, which test is suitable:

Student's t-test

ANOVA

Chi-square test

None of the above

48. Which of the following radiations have higher energy than the visible light?

IRand UV

UV and microwave

X-rays and UV

y-rays and X-rays

49. Chromatography is a technique used to

Separate components in a mixture

Identify the components in a mixture

Modify the components in a mixture

Quantitate the components in a mixture

50. Reactions that have positive standard free energy changes can be made to occur in cells by

coupling them with exergonic reactions via a common intermediate

coupling them with endergonic reactions via a common intermediate

coupling them to the hydrolysis ofATP

doubling the concentration of the reactants

51. Which of the following molecules will have maximum number of stereoisomers?

<img src='./qimages/16039-51.jpg'>

I

II

III

IV

52. Which of the following conjugated dienes would not react with a dienophile in a Diels-Alder reaction?

<img src='./qimages/16039-52.jpg'>

I

II

III

IV

53. Which of the following structures represents a cis isomer?

<img src='./qimages/16039-53.jpg'>

I

II

III

IV

54. DNA synthesis occurs in limited portion of the cell cycle in

mouse cells

cyanobacteria

Escherichia coli

HeLa cells

55. The Maxim-Gilbert method of determining a DNA sequence involves the use of

restriction endonuclease

electrophoresis

electron microscopy

end labeling

56. Catabolite repression, a mechanism of gene control in prokaryotes.

is mediated through cAMP

is mediated through CAP

Results in de novo synthesis of positive activator protein

is caused by several sugars

57. The glycolytic pathway requires one or more of the following allosteric regulatory enzymes?

Hexokinase

Phosphofructokinase

Aldolase

Pyruvate kinase

58. Which of the following compounds has a higher group transfer potential than adenosine triphosphate?

Glucose 6 phosphate

Phosphoenolpyruvate

Phosphocreatine

Fructose 6 phosphate

59. Which of the following are monomers in RNA?

Thymidine

Guanosine

Uridine

Adenosine monophosphate

60. Which of the following statements are true for bacterial DNA replication?

RNA primer required to initiate synthesis

Both to and to strands are replicated simultaneously

initiates at multiple sites in the genome

Okazaki fragments are produced during leading strand synthesis

61. During fasting, liver glycogen is the source of glucose for other tissues, however muscle glycogen is not. What is the explanation for this?

Muscle glycogen is highly branched

Muscle does not have a debranching enzyme

Muscle lacks glucose-6-phosphatase

Muscle lacks glucose-I-phosphatase

62. Which of the following extraembryonic membranes give rise to fetal placenta and umbilical cord in placental mammals?

chorion

allantois

yolk sac

maternal uterine tissue

63. A new species of bacteria was isolated from marshy land near your house. You subjected the bacteria to staining. For staining, the bacterial smear was first flooded with crystal violet, followed by iodine. This was followed by treating the bacterial smear with 95% ethyl alcohol or acetone. At the end, the smear was flooded with red coloured dye safran in, washed and viewed using a light-microscope under oil-immersion. You observed that the new species of bacteria appeared red or pinkish. Which of the following statements may be true for the new found bacteria?

It is Gram negative

It is Gram positive

It may be expected to have a very thick peptidoglycan layer in the cell wall

It may be expected to have high lipopolysaccharide in the outer membrane

64. Which of the following hormones respond to hypoglycemia?

Ghrelin hormone

glucagon

cortisol

epinephrine

65. Which one of the following statements is true for DNA?

is more susceptible than RNA to degradation at high pH.

can hybridize with other DNA and RNA molecules.

is a polymer of nucleotides containing a 6-carbon sugar

has fewer hydroxyl groups than RNA

66. The major products of the hydrolysis of starch by amylase are

Maltose, lactose and limit dextrins

Maltotriose, limit dextrins, and glucose

Glucose, maltose and maltotriose

Maltose, maltotriose and limit dextrins

67. Which of the following play a role in the formation of quaternary structure of proteins?

Hydrogen bonds

Disulfide linkages

Hydrophobic interactions

Electrostatic interactions

68. Which of the following lipids are present in the plasma membrane of mammalian cell?

Cholesterol

Phosphotidylcholine

Cardiolipin

Phosphotidylethanolamine

69. During DNA replication if base analogues are present, mutations are introduced. What types of mutations are most likely to be produced by these mutagens?

transition

transversion

inversion

duplication

70. Oxygen saturation curve of hemoglobin is shown below. Which of the following will shift the oxygen saturation curve to the right?

<img src='./qimages/16039-70.jpg'>

increased

decreased CO2

decreased 2,3-bisphosphoglycerate

increased 2,3-bisphosphoglycerate

71. The blood calcium levels are lowered by the deficiency of which of the following hormone?

Calcitonin

Parathormone

Cortisol

Thyroxine

72. An uncoupler of oxidative phosphorylation would most likely lead to:

Inability to produce heat by the operation of the electron transport chain.

Operation of the electron transport chain without ATP production.

A dependence on ADP for the electron transport chain to operate.

Inability to oxidize NADH by the electron transport chain.

73. In Drosophila, normal wings are dominant over curly wings and brown body colour is dominant over yellow body colour. What types of gametes will be produced by a Drosophila fly that has normal wings and brown body colour with a genotype of homozygous normal wings and heterozygous brown body colour.

50% CB and 50% cb

All Cb

50% each of Cb and cB

50% CB and 50% Cb

74. Oxidation number of phosphorous in Ba(H2PO4)2 is









75. Match the blood clotting factors given in column 1 with their role in blood clotting cascade/event in column 2

Column 1 Column 2

1. Factor X a. causes platelets to aggregate in positive-feedback fashion

2. Plasmin b. fibrinolytic enzyme

3. Factor XII c. a co-factor in prothrombinase complex

4. Factor VIII d. first factor to be activated in intrinsic clotting pathway

5. Factor XIII e. stabilizes thrombin clot in presence of Ca2

6. Prostacyclin f. inhibits platelet aggregation

g. activates thrombin

h. helps in activation of factor X in intrinsic pathway

6-f

6-f

6-f

6-a

76. If cholecystokinin B receptors are completely blocked using a ligand, which of the following hormones associated with gastro-intestinal physiology will display increased circulating levels?

insulin

cholecystokinin

gastrin

secretin

77. Which of the following statements about antigenic determinants on immunoglobulins is INCORRECT?

Isotypic determinants are located in constant regions of heavy and light chains

Idiotypic determinants are located within variable regions of heavy and light chains

Injection of antibodies from one animal to another animal of the same species induces generation of allotypic antibodies

Allotypic determinants are located only in constant regions of heavy chains

78. The set of numbers 10.5, 15, 16.5, 13.5,20,21,14,16,16.5,11,11.5,14,15,21,21, 13.5,14 has an arithmetic mean of 16 and mode of 14. Then, P x

224

264

336

364

79. OD of a benzaldehyde solution measured in spectrophotometer was found to be 0.527. Given the molar absorption coefficient as 1.38x102M)cm^-1,findoutthenumber of micromoles of benzaldehyde present in a 200 ML solution? (path length=0.57 cm)

0.134

0.67

6.7

1.34

80. In some mammalian cells the rate of addition of nucleotide is about of that of E. coli. How many replication origins must fire in a mammalian cell containing 3 pg of DNA per cell and replicating in 6 hours? [Given: the molecular weight of E. coli genome is 2 x 10^9 Da. It takes 40 minutes to replicate E. coli genome].

160

1600

16000

160000

81. One cell of E. coli contains about 10^-14 g of DNA. A DNA strand is 20 A wide and has a mass of about 2xl0^6 Da for each micrometer of length. What fraction of the volume of E. coli is DNA? [Given: the volume of E. coli is about 2.4 x 10^-12 cm^3

0.0004

0.004

0.04

0.4

82. Mountain goats usually come in three colours: Black, white or grey. Trait is encoded by a single locus "B" that shows incomplete dominance. Black is "BB", white is "bb" and grey are "Bb". What would be the genotype and phenotype of offsprings when a black goat mates with a white goat?

Genotype: BB, Bb, bb Phenotype: black, grey and white

Genotype: BB, bb Phenotype: black and white

Genotype: Bb Phenotype: grey

Genotype: Bb Phenotype: black and white

83. A bag contains 5 red marbles, 4 green marbles and 1 blue marble. A marble is chosen at random from the bag and is not replaced. A second marble is chosen after that. What is the probability that neither marble is blue?

2/15

4/15

2/5

9/10

84. What is the probability of drawing a king first and then drawing a king again the second time, from a deck of 52 cards?

4/52

2/52

1/221

2/221

85. The pKa of acetic acid is 4.76. What is the pH of a 0.1 M solution of acetic acid?

5.76

2.88

2.43

4.76